Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer.
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Inhibition of topoisomerase I prevents chromosome breakage at common fragile sitesIdentification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencingCommon fragile sites: genomic hotspots of DNA damage and carcinogenesisGene synteny comparisons between different vertebrates provide new insights into breakage and fusion events during mammalian karyotype evolutionChromosomal instability in Afrotheria: fragile sites, evolutionary breakpoints and phylogenetic inference from genome sequence assembliesSomatic alpha-synuclein mutations in Parkinson's disease: hypothesis and preliminary data.A 6.4 Mb duplication of the α-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations.Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites.Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cellsA whole genome association study of mother-to-child transmission of HIV in Malawi.Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma.Common fragile sites are conserved features of human and mouse chromosomes and relate to large active genes.Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.Is mammalian chromosomal evolution driven by regions of genome fragility?Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.A genome-wide analysis of common fragile sites: what features determine chromosomal instability in the human genome?NEpiC: a network-assisted algorithm for epigenetic studies using mean and variance combined signalsThe role of DNA damage response pathways in chromosome fragility in Fragile X syndrome.Cytogenetic alterations and their molecular genetic correlates in head and neck squamous cell carcinoma: a next generation window to the biology of disease.Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes.Interplay between genetic and epigenetic factors governs common fragile site instability in cancer.Very large common fragile site genes and their potential role in cancer development.FAM190A rearrangements provide a multitude of individualized tumor signatures and neo-antigens in cancer.WWOX, large common fragile site genes, and cancer.Genome position and gene amplificationThe "enemies within": regions of the genome that are inherently difficult to replicate.Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability.DMD and IL1RAPL1: two large adjacent genes localized within a common fragile site (FRAXC) have reduced expression in cultured brain tumors.Common fragile sites (CFS) and extremely large CFS genes are targets for human papillomavirus integrations and chromosome rearrangements in oropharyngeal squamous cell carcinoma.A selected group of large common fragile site genes have decreased expression in oropharyngeal squamous cell carcinomas.Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells.Allelic imbalances and homozygous deletion on 8p23.2 for stepwise progression of hepatocarcinogenesis.Tumors of the upper aerodigestive tract
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P2860
Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Characterization of a conserve ...... inherited disease and cancer.
@en
Characterization of a conserve ...... inherited disease and cancer.
@nl
type
label
Characterization of a conserve ...... inherited disease and cancer.
@en
Characterization of a conserve ...... inherited disease and cancer.
@nl
prefLabel
Characterization of a conserve ...... inherited disease and cancer.
@en
Characterization of a conserve ...... inherited disease and cancer.
@nl
P2093
P2860
P356
P1433
P1476
Characterization of a conserve ...... inherited disease and cancer.
@en
P2093
Eliane El-Achkar
Françoise Apiou
Lorène Rozier
Michelle Debatisse
P2860
P2888
P304
P356
10.1038/SJ.ONC.1207809
P407
P577
2004-09-01T00:00:00Z
P5875
P6179
1049251132