Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo.
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Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein VNerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VIPluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical applicationAspirin induces platelet receptor shedding via ADAM17 (TACE)Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet functionMetalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cellsInfusion of mature megakaryocytes into mice yields functional platelets.Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice.Proteolysis of platelet receptors in humans and other species.FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly.Manipulating megakaryocytes to manufacture platelets ex vivo.Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond.Metalloproteolytic receptor shedding…platelets "acting their age".Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsisp38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivoThe lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation.Minding the gaps to promote thrombus growth and stabilityTransmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha.Combined blockade of ADP receptors and PI3-kinase p110β fully prevents platelet and leukocyte activation during hypothermic extracorporeal circulationDeciphering the human platelet sheddome.TAILS N-terminomics of human platelets reveals pervasive metalloproteinase-dependent proteolytic processing in storage.The influence of intermittent hypoxemia on platelet activation in obese patients with obstructive sleep apnea.An inhibition of p38 mitogen activated protein kinase delays the platelet storage lesion.Platelet glycoprotein Ib beta/IX mediates glycoprotein Ib alpha localization to membrane lipid domain critical for von Willebrand factor interaction at high shearTargeting TACE-dependent EGFR ligand shedding in breast cancer.Dual roles for hepatic lectin receptors in the clearance of chilled plateletsRegulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injurySerotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17)Desialylation accelerates platelet clearance after refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake.Ex vivo recapitulation of trauma-induced coagulopathy and preliminary assessment of trauma patient platelet function under flow using microfluidic technologyStructural basis for the specific inhibition of glycoprotein Ibα shedding by an inhibitory antibodyPlatelet receptor redox regulation.Regulation of mature ADAM17 by redox agents for L-selectin sheddingPlatelet IκB kinase-β deficiency increases mouse arterial neointima formation via delayed glycoprotein Ibα shedding.Platelet hyperreactivity explains the bleeding abnormality and macrothrombocytopenia in a murine model of sitosterolemiaPlatelet clearance via shear-induced unfolding of a membrane mechanoreceptor.Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice.Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion.Semaphorin 7A as a potential immune regulator and promising therapeutic target in rheumatoid arthritis.
P2860
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P2860
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Tumor necrosis factor-alpha-co ...... latelets in vitro and in vivo.
@en
Tumor necrosis factor-alpha-converting enzyme
@nl
type
label
Tumor necrosis factor-alpha-co ...... latelets in vitro and in vivo.
@en
Tumor necrosis factor-alpha-converting enzyme
@nl
prefLabel
Tumor necrosis factor-alpha-co ...... latelets in vitro and in vivo.
@en
Tumor necrosis factor-alpha-converting enzyme
@nl
P2093
P1433
P1476
Tumor necrosis factor-alpha-co ...... latelets in vitro and in vivo.
@en
P2093
Crystal L Piffath
Denisa D Wagner
Guiying Cheng
Vandana S Dole
Wolfgang Bergmeier
Yuhua Zhang
P304
P356
10.1161/01.RES.0000143899.73453.11
P577
2004-09-02T00:00:00Z