Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
about
Secondary structure in the target as a confounding factor in synthetic oligomer microarray designAOBase: a database for antisense oligonucleotides selection and design.Transcription factor Egr-1 regulates glomerular mesangial cell proliferationApproaches to Validate and Manipulate RNA Targets with Small Molecules in CellsMapping of RNA accessible sites by extension of random oligonucleotide libraries with reverse transcriptase.Mapping of accessible sites for oligonucleotide hybridization on hepatitis delta virus ribozymesFast and accurate determination of sites along the FUT2 in vitro transcript that are accessible to antisense oligonucleotides by application of secondary structure predictions and RNase H in combination with MALDI-TOF mass spectrometry.Let them fly or light them up: matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry and fluorescence in situ hybridization (FISH).Construction of a directed hammerhead ribozyme library: towards the identification of optimal target sites for antisense-mediated gene inhibition.Selection of antisense oligonucleotides based on multiple predicted target mRNA structures.Application of equilibrium models of solution hybridization to microarray design and analysisNew approach to real-time nucleic acids detection: folding polymerase chain reaction amplicons into a secondary structure to improve cleavage of Forster resonance energy transfer probes in 5'-nuclease assays.Properties of cloned and expressed human RNase H1.Toward antiviral strategies that resist viral escapeThermodynamic and kinetic characterization of antisense oligodeoxynucleotide binding to a structured mRNAPotential therapeutic application of antisense oligonucleotides in the treatment of ocular diseases.Potential roles of antisense technology in cancer chemotherapy.Unrestricted accessibility of short oligonucleotides to RNAPrioritized selection of oligodeoxyribonucleotide probes for efficient hybridization to RNA transcriptsUse of base modifications in primers and amplicons to improve nucleic acids detection in the real-time snake polymerase chain reaction.Secondary structure effects on DNA hybridization kinetics: a solution versus surface comparison.Rational design of point mutation-selective antisense DNA targeted to codon 12 of Ha-ras mRNA in human cells.Short loop-targeting oligoribonucleotides antagonize Lin28 and enable pre-let-7 processing and suppression of cell growth in let-7-deficient cancer cells.Variables and strategies in development of therapeutic post-transcriptional gene silencing agentsRational design and rapid screening of antisense oligonucleotides for prokaryotic gene modulation.Defining the factors that contribute to on-target specificity of antisense oligonucleotides.Effects of target length on the hybridization efficiency and specificity of rRNA-based oligonucleotide microarraysHybridization specificity, enzymatic activity and biological (Ha-ras) activity of oligonucleotides containing 2,4-dideoxy-beta-D-erythro-hexopyranosyl nucleosidesUse of DNA and peptide nucleic acid molecular beacons for detection and quantification of rRNA in solution and in whole cellsAntisense oligonucleotides in the treatment of bladder cancer.Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy.Precise small-molecule recognition of a toxic CUG RNA repeat expansion.Rational screening of oligonucleotide combinatorial libraries for drug discovery.Effects of local mRNA structure on posttranscriptional gene silencing.A highly emissive fluorescent nucleoside that signals the activity of toxic ribosome-inactivating proteins.Use of extremely short Förster resonance energy transfer probes in real-time polymerase chain reactionOn the biophysics and kinetics of toehold-mediated DNA strand displacementSpecific discrimination of three pathogenic Salmonella enterica subsp. enterica serotypes by carB-based oligonucleotide microarrayGene silencing in the therapy of influenza and other respiratory diseases: Targeting to RNase P by use of External Guide Sequences (EGS).Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy.
P2860
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P2860
Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh-hant
name
Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
@en
Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
@nl
type
label
Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
@en
Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
@nl
prefLabel
Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
@en
Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
@nl
P2093
P356
P1433
P1476
Implication of RNA structure on antisense oligonucleotide hybridization kinetics.
@en
P2093
P304
12055-12061
P356
10.1021/BI00163A013
P407
P577
1992-12-01T00:00:00Z