Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
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Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activityCannabinergic aminoalkylindoles, including AM678=JWH018 found in 'Spice', examined using drug (Δ(9)-tetrahydrocannabinol) discrimination for ratsBeyond THC: The New Generation of Cannabinoid Designer DrugsTargeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligandsSensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- miceAdverse Effects of Synthetic Cannabinoids: Management of Acute Toxicity and WithdrawalMarijuana, Spice 'herbal high', and early neural development: implications for rescheduling and legalizationSpice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoidsDesign, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.[INCREMENT]9-Tetrahydrocannabinol discriminative stimulus effects of AM2201 and related aminoalkylindole analogs in rats.Vaping Synthetic Cannabinoids: A Novel Preclinical Model of E-Cigarette Use in MiceNovel Drugs of Abuse: A Snapshot of an Evolving Marketplace.O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive propertiesFluorinated cannabinoid CB2 receptor ligands: synthesis and in vitro binding characteristics of 2-oxoquinoline derivativesEvaluation of a homogenous enzyme immunoassay for the detection of synthetic cannabinoids in urine"Herbal incense": designer drug blends as cannabimimetics and their assessment by drug discrimination and other in vivo bioassays.JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonistJWH-018 in rhesus monkeys: differential antagonism of discriminative stimulus, rate-decreasing, and hypothermic effects.Cross-substitution of Δ9-tetrahydrocannabinol and JWH-018 in drug discrimination in rats.Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ(9)-tetrahydrocannabinol.Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons.Marijuana-based drugs: innovative therapeutics or designer drugs of abuse?Determination of naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in mouse blood and tissue after inhalation exposure to 'buzz' smoke by HPLC/MS/MS.Severe toxicity following synthetic cannabinoid ingestion.3-Substituted pyrazole analogs of the cannabinoid type 1 (CB₁) receptor antagonist rimonabant: cannabinoid agonist-like effects in mice via non-CB₁, non-CB₂ mechanism.1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in miceAnalysis of synthetic cannabinoids using high-resolution mass spectrometry and mass defect filtering: implications for nontargeted screening of designer drugsThe synthesis and pharmacological evaluation of adamantane-derived indoles: cannabimimetic drugs of abuse.Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids.Δ9-Tetrahydrocannabinol-like discriminative stimulus effects of compounds commonly found in K2/Spice.AB-CHMINACA, AB-PINACA, and FUBIMINA: Affinity and Potency of Novel Synthetic Cannabinoids in Producing Δ9-Tetrahydrocannabinol-Like Effects in MiceBaths salts, spice, and related designer drugs: the science behind the headlines.Crystal Structure of the Human Cannabinoid Receptor CB1.CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonistsA survey study to characterize use of Spice products (synthetic cannabinoids).JWH-018 and JWH-073: Δ⁹-tetrahydrocannabinol-like discriminative stimulus effects in monkeysMetabolism of RCS-8, a synthetic cannabinoid with cyclohexyl structure, in human hepatocytes by high-resolution MS.Synthesis and pharmacology of 1-alkyl-3-(1-naphthoyl)indoles: steric and electronic effects of 4- and 8-halogenated naphthoyl substituentsΔ9-Tetrahydrocannabinol-like effects of novel synthetic cannabinoids found on the gray market.Apparent inverse relationship between cannabinoid agonist efficacy and tolerance/cross-tolerance produced by Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys
P2860
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P2860
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
@en
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
@nl
type
label
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
@en
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
@nl
prefLabel
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
@en
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
@nl
P2093
P1476
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
@en
P2093
P304
P407
P577
1998-06-01T00:00:00Z