Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.
about
Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptomeThe BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca2+ Affinity of the Multi-C2-Domain Protein Otoferlin.Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.What's hot about otoferlin.RIM-Binding Protein 2 Promotes a Large Number of CaV1.3 Ca2+-Channels and Contributes to Fast Synaptic Vesicle Replenishment at Hair Cell Active Zones.Piccolo Promotes Vesicle Replenishment at a Fast Central Auditory Synapse.Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses.The synaptic ribbon is critical for sound encoding at high rates and with temporal precision.
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P2860
Hair cell synaptic dysfunction, auditory fatigue and thermal sensitivity in otoferlin Ile515Thr mutants.
description
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name
Hair cell synaptic dysfunction ...... n otoferlin Ile515Thr mutants.
@en
Hair cell synaptic dysfunction ...... n otoferlin Ile515Thr mutants.
@nl
type
label
Hair cell synaptic dysfunction ...... n otoferlin Ile515Thr mutants.
@en
Hair cell synaptic dysfunction ...... n otoferlin Ile515Thr mutants.
@nl
prefLabel
Hair cell synaptic dysfunction ...... n otoferlin Ile515Thr mutants.
@en
Hair cell synaptic dysfunction ...... n otoferlin Ile515Thr mutants.
@nl
P2093
P2860
P50
P356
P1433
P1476
Hair cell synaptic dysfunction ...... n otoferlin Ile515Thr mutants.
@en
P2093
Alexandra Müller
Carolin Wichmann
Christof Lenz
Elisabeth Auge
Gerhard Hoch
Gulnara Yamanbaeva
Hanan Al-Moyed
Henning Urlaub
Kuan-Ting Pan
Nicola Strenzke
P2860
P304
P356
10.15252/EMBJ.201694564
P407
P577
2016-10-11T00:00:00Z