DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior.
about
An overview of Cdk1-controlled targets and processesCdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrestA mitotic topoisomerase II checkpoint in budding yeast is required for genome stability but acts independently of Pds1/securin.Hsp110 is required for spindle length control.The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilizationThe coordination of centromere replication, spindle formation, and kinetochore-microtubule interaction in budding yeast.Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants.Genome-wide analysis reveals novel and discrete functions for tubulin carboxy-terminal tailsTension-dependent regulation of microtubule dynamics at kinetochores can explain metaphase congression in yeast.Unrestrained spindle elongation during recovery from spindle checkpoint activation in cdc15-2 cells results in mis-segregation of chromosomesFunctional characterization of the Saccharomyces cerevisiae protein Chl1 reveals the role of sister chromatid cohesion in the maintenance of spindle length during S-phase arrestSlx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4Topoisomerase II- and condensin-dependent breakage of MEC1ATR-sensitive fragile sites occurs independently of spindle tension, anaphase, or cytokinesis.Modulation of cell cycle-specific gene expressions at the onset of S phase arrest contributes to the robust DNA replication checkpoint response in fission yeast.Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases.Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae.An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth.The yeast S phase checkpoint enables replicating chromosomes to bi-orient and restrain spindle extension during S phase distressOrchestration of the S-phase and DNA damage checkpoint pathways by replication forks from early originsMitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation.Unreplicated DNA in mitosis precludes condensin binding and chromosome condensation in S. cerevisiae.Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae.Centromere replication timing determines different forms of genomic instability in Saccharomyces cerevisiae checkpoint mutants during replication stress.The DNA damage checkpoint response to replication stress: A Game of Forks.The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase.Replicative stress induces intragenic transcription of the ASE1 gene that negatively regulates Ase1 activity.Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (Drosophila Chk1).The spindle assembly checkpoint regulates the phosphorylation state of a subset of DNA checkpoint proteins in Saccharomyces cerevisiaeReplication checkpoint: tuning and coordination of replication forks in s phase.Genotoxic stress prevents Ndd1-dependent transcriptional activation of G2/M-specific genes in Saccharomyces cerevisiae.G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint.Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast.Spc24 and Stu2 promote spindle integrity when DNA replication is stalled.The function and regulation of budding yeast Swe1 in response to interrupted DNA synthesis.Checking in on spindle size.Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication."Reductional anaphase" in replication-defective cells is caused by ubiquitin-conjugating enzyme Cdc34-mediated deregulation of the spindle.
P2860
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P2860
DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
DNA replication checkpoint pre ...... y regulating spindle behavior.
@en
DNA replication checkpoint pre ...... y regulating spindle behavior.
@nl
type
label
DNA replication checkpoint pre ...... y regulating spindle behavior.
@en
DNA replication checkpoint pre ...... y regulating spindle behavior.
@nl
prefLabel
DNA replication checkpoint pre ...... y regulating spindle behavior.
@en
DNA replication checkpoint pre ...... y regulating spindle behavior.
@nl
P2093
P1433
P1476
DNA replication checkpoint pre ...... y regulating spindle behavior.
@en
P2093
Alison Yi Hui Cheng
Saurabh Nirantar
Vaidehi Krishnan
P304
P356
10.1016/J.MOLCEL.2004.11.001
P577
2004-12-01T00:00:00Z