Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia. - Wikidata - wikimedia - TriplyDB

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia.

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q45209344

about

Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Genetic methylation and lymphoid malignancies: biomarkers of tumor progression and targeted therapy.Novel agents for the treatment of childhood acute leukemia.Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia.Disease-drug pairs revealed by computational genomic connectivity mapping on GBA1 deficient, Gaucher disease mice.Collaborative Efforts Driving Progress in Pediatric Acute Myeloid Leukemia.Treatment of infant leukemias: challenge and promise.The genomic landscape of breast cancer as a therapeutic roadmap MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.c-Myc suppresses miR-451⊣YWTAZ/AKT axis via recruiting HDAC3 in acute myeloid leukemia.The evolution of clinical trials for infant acute lymphoblastic leukemia.SIAH proteins: critical roles in leukemogenesis.In focus: MLL-rearranged leukemia.RUNX1 meets MLL: epigenetic regulation of hematopoiesis by two leukemia genes.Epigenetic regulation of cell signaling pathways in acute lymphoblastic leukemia.Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.Novel methods and approaches to acute lymphoblastic leukemia drug discovery.The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis.How do tumor cells respond to HDAC inhibition?Selective Inhibition of HDAC1 and HDAC2 as a Potential Therapeutic Option for B-ALL.The development of targeted new agents to improve the outcome for children with leukemia.Gene expression signature-based approach identifies a pro-resolving mechanism of action for histone deacetylase inhibitors.AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3 Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL.Entinostat prevents leukemia maintenance in a collaborating oncogene-dependent model of cytogenetically normal acute myeloid leukemia.The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL.Outcome of relapsed infant acute lymphoblastic leukemia treated on the interfant-99 protocol.Childhood relapsed acute lymphoblastic leukemia: Biology and recent treatment progress.

P2860

Q28817780-F62A56D8-8AF8-40DC-90F0-0362E23D9C84 Q33666543-8009BE95-4C58-4453-B68D-85756EEE7DA9 Q33913937-52706557-D9D9-4A87-9205-0C618D0ED5DD Q35192790-3814BD25-9E05-48C1-B01F-EBF0BDDD0A0E Q36015007-B9B740FE-29FC-475B-B6F5-22F987A51688 Q36040753-44BC7635-0470-4DAF-8C8B-16AE638B5ED0 Q36053792-119C1B39-4DB8-467E-B1D9-CD11C9D8554D Q36508988-A97A0560-A202-4DA9-9697-E798C7696903 Q36558069-3FA7902D-E522-46C9-BBF1-FD904D2A9D14 Q37633585-89F1916B-9BB6-481C-AEC7-E490503B376E Q37718379-55793ACA-58BE-4D14-81DC-CABC5D926452 Q37730023-5242797E-2729-478A-9E1A-86207A75BDF4 Q38049544-11920528-4D48-4508-AF76-0F2D3369038A Q38091585-6D21C396-3E26-479E-8C50-B8CC066A95DF Q38118553-B360791B-9EA4-4803-81BC-F6175793E665 Q38141135-02F1D84B-CB97-4FA5-9B54-F5AA6C7A09C8 Q38240733-A532E129-E9CA-489B-B2EA-7510363CE740 Q38248461-7787765C-4DB1-4BDD-B611-2274C8B37841 Q38687570-F1B8D923-8750-497F-A22B-2976EF57B8BD Q38817005-B175BF85-FF4B-446F-B8DA-56EB350409E1 Q38908846-31B663FA-B0DF-47FF-83C4-A61009D7D7B5 Q38964974-69FE8F19-273C-4322-98B2-FD43F061A497 Q39230228-83D11F2E-4786-4F18-AE83-F727A6AD54A7 Q41546163-D3C5A730-BB94-4E33-9D1C-7697E34E5AC4 Q42536195-BF13C365-223D-4A26-8F4B-DB69E8DA63D3 Q45754556-FF86B446-6209-4B85-93F4-9F97A4DB77F3 Q48090552-D6BE70BF-A666-4536-8EB9-5344F848E17C Q50854409-0A314542-F5DC-47BC-A75B-9963D974AF5B Q53814000-7D74DB26-9249-47EC-BDF7-93AEA3E52513

P2860

Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q45209344

description

2011 nî lūn-bûn

@nan

2011年の論文

@ja

2011年学术文章

@wuu

2011年学术文章

@zh

2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

2011年學術文章

@zh-hant

name

Connectivity mapping identifies HDAC inhibitors for the treatment of t

@nl

Connectivity mapping identifie ...... acute lymphoblastic leukemia.

@en

type

label

Connectivity mapping identifies HDAC inhibitors for the treatment of t

@nl

Connectivity mapping identifie ...... acute lymphoblastic leukemia.

@en

prefLabel

Connectivity mapping identifies HDAC inhibitors for the treatment of t

@nl

Connectivity mapping identifie ...... acute lymphoblastic leukemia.

@en

P1433

Q45209344-BCAE0314-5A10-4E54-A8CF-9466C4095022

P1476

Q45209344-80C26E43-F923-4236-B146-8F41F0CC9BB0

P2093

Q45209344-8B3B8244-5B6F-49CA-9741-E8B1D6A419A3

Q45209344-92550AA4-2E0E-4FF5-BF04-7CA8013C4240

Q45209344-AFC838B6-3EC4-44BE-87E4-312B06F884DC

Q45209344-B76390A6-6B54-45D4-A6E2-B521C64BDBE7

Q45209344-C0DAC85B-6347-415C-A813-E49A5689D690

Q45209344-C2B8E7DD-9B9B-4984-8B06-AB77CE022ADE

Q45209344-F5B3EFD5-7CC6-4C63-B88D-968169883B16

P2860

Q45209344-07AB02AF-C6A6-40B1-923F-82C119A68C11

Q45209344-11C5BD0E-50A3-4C88-B7F8-BAEB8F3FE9A9

Q45209344-11D6959D-4D27-479C-B43D-B68C2F00D91D

Q45209344-13D1D8A4-1943-458B-9F8D-665DACC68E23

Q45209344-29AABFBF-A151-4933-84E0-315922DC2C89

Q45209344-2A40B4EB-8C66-4885-987A-DE22BF01A030

Q45209344-2FB44FB5-E345-46E3-BCE3-D3E5EC6EF040

Q45209344-30BAD9A9-7F8D-4B8E-8F57-CCBB1C62085B

Q45209344-30E15686-5800-4F47-B6F6-698B68424173

Q45209344-322DB85E-42E8-4284-BB8D-29FE987EA593

P2888

Q45209344-8F440290-4C5D-41FB-BCCC-E45429982ABF

P304

Q45209344-D2BBB65E-0686-4BEA-8ACD-8A9053C8931F

P31

Q45209344-3897128A-8351-473C-B517-79949B75969A

P356

Q45209344-0CCDA503-3AC7-47B9-B9BB-B70C0710EDC9

P433

Q45209344-DE3927CE-CD33-446D-8698-9ACABE6D1807

P478

Q45209344-E85FAB2F-7D39-4615-AC34-5B3BA437D171

P577

Q45209344-050AF19A-05E7-49E6-A9B2-1CB9FF959949

P6179

Q45209344-7C580A11-6D95-4A9D-BF1C-61CF20AAD435

P698

Q45209344-7BE2A930-9E8F-4C1B-B67B-94FA8A9BABCC

P921

Q45209344-77189E2B-25B1-49F4-85C2-CB7655221BAA

P356

P1433

P1476

Connectivity mapping identifie ...... acute lymphoblastic leukemia.

@en

P2093

D J P M Stumpel

http://www.w3.org/2001/XMLSchema#string

H Osaki

http://www.w3.org/2001/XMLSchema#string

L Seslija

http://www.w3.org/2001/XMLSchema#string

O Williams

http://www.w3.org/2001/XMLSchema#string

P Schneider

http://www.w3.org/2001/XMLSchema#string

R Pieters

http://www.w3.org/2001/XMLSchema#string

R W Stam

http://www.w3.org/2001/XMLSchema#string

P2860

MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing

The RUNX genes: gain or loss of function in cancer

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

The Connectivity Map: a new tool for biomedical research

MLL targets SET domain methyltransferase activity to Hox gene promoters

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

GenePattern 2.0

P2888

P304

682-692

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/LEU.2011.278

http://www.w3.org/2001/XMLSchema#string

P433

4

http://www.w3.org/2001/XMLSchema#string

P478

26

http://www.w3.org/2001/XMLSchema#string

P577

2011-10-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P6179

1045480274

http://www.w3.org/2001/XMLSchema#string

P698

22015773

http://www.w3.org/2001/XMLSchema#string

P921