Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin.
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Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and PerspectivesMaximising the potential of AKT inhibitors as anti-cancer treatmentsThe phosphoinositide 3-kinase pathway and therapy resistance in cancerColocalized delivery of rapamycin and paclitaxel to tumors enhances synergistic targeting of the PI3K/Akt/mTOR pathway.Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting.A phase-1b study of everolimus plus paclitaxel in patients with small-cell lung cancer.Conditional drug screening shows that mitotic inhibitors induce AKT/PKB-insensitive apoptosisRapamycin potentiates the effects of paclitaxel in endometrial cancer cells through inhibition of cell proliferation and induction of apoptosis.Phase II study of docetaxel in combination with everolimus for second- or third-line therapy of advanced non-small-cell lung cancer.Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer.Variable expression of PIK3R3 and PTEN in Ewing Sarcoma impacts oncogenic phenotypes.MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells.FoxO limits microtubule stability and is itself negatively regulated by microtubule disruptionInfluence of Alternative Tubulin Inhibitors on the Potency of a Epirubicin-Immunochemotherapeutic Synthesized with an Ultra Violet Light-Activated Intermediate: Influence of incorporating an internal/integral disulfide bond structure and AlternativeAntitumor activity of Triolimus: a novel multidrug-loaded micelle containing Paclitaxel, Rapamycin, and 17-AAG.Enhanced Antitumor Activity with Combining Effect of mTOR Inhibition and Microtubule Stabilization in Hepatocellular Carcinoma.Co-loaded paclitaxel/rapamycin liposomes: Development, characterization and in vitro and in vivo evaluation for breast cancer therapy.Effects for Sequential Treatment of siAkt and Paclitaxel on Gastric Cancer Cell Lines.Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia.Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulationDeletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cellsA phase 1 study of weekly everolimus (RAD001) in combination with docetaxel in patients with metastatic breast cancer.Microtubule-targeting agents in oncology and therapeutic potential in hepatocellular carcinoma.Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro.Utility of mTOR inhibition in hematologic malignancies.Effects of mTOR inhibitors and cytoskeletal-directed agents alone and in combination against normal and neoplastic hematopoietic cells in vitro.The tubulin inhibitor MG-2477 induces autophagy-regulated cell death, ROS accumulation and activation of FOXO3 in neuroblastomaPI3K/Akt pathway activation attenuates the cytotoxic effect of methyl jasmonate toward sarcoma cells.Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cellsAnti-Neoplastic Cytotoxicity of Gemcitabine-(C4-amide)-[anti-HER2/neu] in Combination with Griseofulvin against Chemotherapeutic-Resistant Mammary Adenocarcinoma (SKBr-3).mTOR in viral hepatitis and hepatocellular carcinoma: function and treatment.Rapamycin induces transactivation of the EGFR and increases cell survival.Triolimus: A Multi-Drug Loaded Polymeric Micelle Containing Paclitaxel, 17-AAG, and Rapamycin as a Novel Radiosensitizer.
P2860
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P2860
Akt up-regulation increases resistance to microtubule-directed chemotherapeutic agents through mammalian target of rapamycin.
description
2004 nî lūn-bûn
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2004年の論文
@ja
2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
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2004年學術文章
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name
Akt up-regulation increases re ...... mammalian target of rapamycin.
@en
Akt up-regulation increases re ...... mammalian target of rapamycin.
@nl
type
label
Akt up-regulation increases re ...... mammalian target of rapamycin.
@en
Akt up-regulation increases re ...... mammalian target of rapamycin.
@nl
prefLabel
Akt up-regulation increases re ...... mammalian target of rapamycin.
@en
Akt up-regulation increases re ...... mammalian target of rapamycin.
@nl
P1476
Akt up-regulation increases re ...... mammalian target of rapamycin
@en
P2093
Charles M Rudin
Rixin Zhou
P304
P577
2004-12-01T00:00:00Z