Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion.
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Methods, potentials, and limitations of gene delivery to regenerate central nervous system cellsEffective gene therapy in an authentic model of Tay-Sachs-related diseasesImaging the response of the retina to electrical stimulation with genetically encoded calcium indicators.Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice.Efficient gene delivery and selective transduction of glial cells in the mammalian brain by AAV serotypes isolated from nonhuman primates.Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primatesNovel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates.Comparison of Endovascular and Intraventricular Gene Therapy With Adeno-Associated Virus-α-L-Iduronidase for Hurler DiseaseTiter and product affect the distribution of gene expression after intraputaminal convection-enhanced delivery.Selective injection system into hippocampus CA1 via monitored theta oscillationStriatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model.An amplified promoter system for targeted expression of calcium indicator proteins in the cerebellar cortex.Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior.Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex.Diffusion of macromolecules in the brain: implications for drug delivery.Insulin growth factor-1 gene transfer enhances neurovascular remodeling and improves long-term stroke outcome in mice.The MRI contrast agent gadoteridol enhances distribution of rAAV1 in the rat hippocampus.Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways.Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector.Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain.Postischemic IGF-1 gene transfer promotes neurovascular regeneration after experimental stroke.Mannitol-facilitated CNS entry of rAAV2 vector significantly delayed the neurological disease progression in MPS IIIB mice.Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic miceEfficient CNS gene delivery by intravenous injection.Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice.Intracisternal rSV40 administration provides effective pan-CNS transgene expression.
P2860
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P2860
Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Systemic mannitol-induced hype ...... extent than local co-infusion.
@en
Systemic mannitol-induced hype ...... extent than local co-infusion.
@nl
type
label
Systemic mannitol-induced hype ...... extent than local co-infusion.
@en
Systemic mannitol-induced hype ...... extent than local co-infusion.
@nl
prefLabel
Systemic mannitol-induced hype ...... extent than local co-infusion.
@en
Systemic mannitol-induced hype ...... extent than local co-infusion.
@nl
P2093
P1433
P1476
Systemic mannitol-induced hype ...... extent than local co-infusion.
@en
P2093
Frederic N Nguyen
Ronald J Mandel
P304
P356
10.1016/J.YMTHE.2004.08.031
P577
2005-02-01T00:00:00Z