Polyglutamines, nuclear inclusions and neurodegeneration.
about
Pathogenesis of inclusion bodies in (CAG)n/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability.Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.Molecular clearance of ataxin-3 is regulated by a mammalian E4Recruitment and the role of nuclear localization in polyglutamine-mediated aggregation.Transglutaminase aggregates huntingtin into nonamyloidogenic polymers, and its enzymatic activity increases in Huntington's disease brain nuclei.UBE4B: a promising regulatory molecule in neuronal death and survival.Genetic variants in diseases of the extrapyramidal system.PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond.CAG repeats mimic CUG repeats in the misregulation of alternative splicing.Intracellular processing and toxicity of the truncated androgen receptor: nuclear congophilia-associated cell death.Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro.Polyglutamine-induced ion channels: a possible mechanism for the neurotoxicity of Huntington and other CAG repeat diseases.SUMO-Targeted Ubiquitin Ligases (STUbLs) Reduce the Toxicity and Abnormal Transcriptional Activity Associated With a Mutant, Aggregation-Prone Fragment of HuntingtinVariation on a trinucleotide theme
P2860
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P2860
Polyglutamines, nuclear inclusions and neurodegeneration.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh-hant
name
Polyglutamines, nuclear inclusions and neurodegeneration.
@en
Polyglutamines, nuclear inclusions and neurodegeneration.
@nl
type
label
Polyglutamines, nuclear inclusions and neurodegeneration.
@en
Polyglutamines, nuclear inclusions and neurodegeneration.
@nl
prefLabel
Polyglutamines, nuclear inclusions and neurodegeneration.
@en
Polyglutamines, nuclear inclusions and neurodegeneration.
@nl
P2860
P356
P1433
P1476
Polyglutamines, nuclear inclusions and neurodegeneration.
@en
P2093
P2860
P2888
P304
P356
10.1038/NM1197-1201
P407
P577
1997-11-01T00:00:00Z
P6179
1051940282