Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models. - Wikidata - wikimedia - TriplyDB

Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.

Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.

http://www.wikidata.org/entity/Q45304771

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Multiple Aspects of Gene Dysregulation in Huntington's Disease Cocaine alters BDNF expression and neuronal migration in the embryonic mouse forebrain The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases Nucleolar dysfunction in Huntington's disease Epigenetic Regulation of Immunological Alterations Following Prenatal Exposure to Marijuana Cannabinoids and its Long Term Consequences in Offspring Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II.Epigenetic Changes in Neurodegenerative Diseases Molecular mechanisms of synaptic remodeling in alcoholism The promise and perils of HDAC inhibitors in neurodegeneration Epigenetic mechanisms of neurodegeneration in Huntington's disease Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease Alterations in brain-derived neurotrophic factor in the mouse hippocampus following acute but not repeated benzodiazepine treatment Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease Multiple phenotypes in Huntington disease mouse neural stem cells.Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders Epigenetic inheritance of a cocaine-resistance phenotype.Genetic knock-down of HDAC7 does not ameliorate disease pathogenesis in the R6/2 mouse model of Huntington's disease Age-associated chromatin relaxation is enhanced in Huntington's disease mice.Pharmacology of epigenetics in brain disorders Histone modifications are associated with Δ9-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses The polyubiquitin Ubc gene modulates histone H2A monoubiquitylation in the R6/2 mouse model of Huntington's disease.Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine.Epigenetic memory: the Lamarckian brain Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease.Histone methylation and acetylation indicates epigenetic change in the aged cochlea of mice.MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms Transcription, epigenetics and ameliorative strategies in Huntington's Disease: a genome-wide perspective Huntington's Disease and Striatal Signaling.Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease Polyglutamine (polyQ) disorders: the chromatin connection.Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington's disease.Poly-glutamine expanded huntingtin dramatically alters the genome wide binding of HSF1.Extensive changes in DNA methylation are associated with expression of mutant huntingtin.CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington's disease.Epigenetics in nucleotide repeat expansion disorders.DNA methylation in Huntington's disease: Implications for transgenerational effects

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P2860

Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models.

http://www.wikidata.org/entity/Q45304771

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2007 nî lūn-bûn

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Histones associated with downr ...... n Huntington's disease models.

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Histones associated with downr ...... n Huntington's disease models.

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Histones associated with downr ...... n Huntington's disease models.

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Caroline L Benn

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Eva Xia

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George J Yohrling

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Prianka Chawla

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Ryan P Overland

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10.1093/HMG/DDM078

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11

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Timothy W. Clark

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Huntington disease