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Sensing of DNA Double Strand Breaks

Sensing of DNA Double Strand Breaks

http://www.wikidata.org/entity/Q45314234

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Formation of RAD50:MRE11 complex NBN binds KPNA2 KPNA2 translocates NBN to the nucleus Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction

P361

DNA Double Strand Break Response

P527

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P361

Q45314232-12FF85A5-3E7D-422C-B67B-37864143CAF0

P527

Sensing of DNA Double Strand Breaks

http://www.wikidata.org/entity/Q45314234

description

An instance of the biological pathway Sensing of DNA Double Strand Breaks in Homo sapiens

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name

Sensing of DNA Double Strand Breaks

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type

label

Sensing of DNA Double Strand Breaks

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prefLabel

Sensing of DNA Double Strand Breaks

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P2860

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P2888

Q45314234-BCA69BD2-83D9-40E1-8450-C6238673A210

P31

Q45314234-D82D1338-8F85-4A50-90A9-EB23CCFC2116

P361

Q45314234-01F13EFB-3023-407D-87C0-683A3332AE7F

P3937

Q45314234-0F53567C-EADB-40BA-AFB8-D57C87E59837

P527

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Q45314234-CE78AD74-D73D-4C88-B9B3-2CDDE81E07CE

Q45314234-D19060D9-EEE9-424D-95BF-43D9B3689489

P703

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P2860

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

The DNA Damage Response: Making It Safe to Play with Knives

Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Recombinational DNA repair and human disease

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.

P2888

reactome:R-HSA-5693548

P31

biological pathway

P361

DNA Double Strand Break Response

P3937

R-HSA-5693548

http://www.w3.org/2001/XMLSchema#string

P527

DSB inducing agents induce double strand DNA breaks

MRN complex binds DNA double strand breaks

MRN complex bound to DNA ends recruits ATM

KAT5 acetylates ATM at DNA DSBs

MRN activates ATM

Formation of RAD50:MRE11 complex

NBN binds KPNA2

KPNA2 translocates NBN to the nucleus

Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction

P703