about
Envoplakin binds periplakinEVL:PPL heterodimer binds the inner surface of the plasma membraneTGM1 and involucrin bind the plasma membraneEnvoplakin; periplakin; involucrin; SPR binding mediated by TGM1 crosslinkingMembrane proteases cleave Profilaggrin producing FilaggrinCytoplasmic proteases cleave Profilaggrin producing FilaggrinFilaggrin binds Keratin tonofilament:DesmosomeFillagrin and keratin intermediate filaments polymerise forming a networkReinforcement of the Cornified EnvelopeLamellar bodies bind the early cornified envelopeCDSN binds the cornified envelopeLate envelope proteins bind cornified envelope:CDSNCASP14 cleaves filaggrinPlasma membrane resorptionPERP binds desmosomesKazrin binds periplakinST14 hydrolyzes and activates KLK5SPINK5(490-624) binds KLK5Dissociation of the SPINK5:KLK5 complex at low pHKLK5 cleaves and activates CELA2KLK5 cleaves and activates KLK8SPINK6 binds KLK12SPINK6 binds KLK13SPINK6 binds KLK14SPINK6 binds KLK5SPINK9 binds KLK5LIPs hydrolyse TG to DAG and RCOOH
P361
P527
Q50288510-A3049B39-3657-4944-ACEA-EA3C59439ACAQ50288511-F7670B17-374D-43D3-A8C0-D700C2B3B552Q50288514-42B53EEC-CCFF-46A1-8F58-24F1B2341055Q50288515-B7BC19A8-4802-4754-8E75-212F3B36C97DQ50288516-A25F0CB9-8136-4892-B358-F280B123CAFEQ50288518-6FAE01AA-3534-4D55-8154-18F7878ADB85Q50288519-799BEFE7-8220-4305-843A-556F353CBC86Q50288521-01FC9772-4028-4531-80E8-F139121394EDQ50288522-1F0B718B-4BA4-4743-8E98-BE9EFFFCA3DDQ50288524-C4ED2690-50C4-4B24-B3DD-FB8A088117BBQ50288525-82AF76D6-B9C6-45A3-BBD1-52EB251FC8F2Q50288526-103636BE-30B2-479F-A4DF-36C74FB56845Q50288527-7AA8523B-FF3B-4880-807C-8059BE2B13ACQ50288528-53ADC57E-F466-42C8-9660-BC0C8A741722Q50288530-1410092C-0269-4B8C-B75E-0C96CDB14231Q50288531-779E6135-563E-46A9-9146-E7C1695A30D3Q50288532-7929FE09-AE40-4FC8-B13A-0653AFDD4941Q50288534-A6560238-1DD8-48BB-AAB8-B48786BDE56FQ50288535-27F7F1AA-254A-4260-BAFF-2B57A3AF7DDEQ50288537-81EE7670-8F27-46AA-A17C-2EDCB1155F4FQ50288539-07E1CD0D-0EF5-4417-93A2-803D8AC5D693Q50288541-56F081B3-E15B-446E-B02E-DDD8FD7D5E13Q50288542-182CCD9D-7BEA-47B4-9826-E2FA41993B2EQ50288543-4D6254CD-750A-4071-A2B6-FF1C920C9962Q50288545-7793B889-9262-4DFA-8335-52ED00DAA8FCQ50288547-57F9E8BA-4BF3-4624-99E4-4AB12FE42A13Q50288548-9030DDB9-F077-4247-A1AC-7B759E23D6E1
P361
description
An instance of the biological pathway Formation of the cornified envelope in Homo sapiens
@en
name
Formation of the cornified envelope
@en
type
label
Formation of the cornified envelope
@en
prefLabel
Formation of the cornified envelope
@en
P527
P361
P3937
R-HSA-6809371