Constitutive Signaling by Aberrant PI3K in Cancer - Wikidata - wikimedia - TriplyDB

Constitutive Signaling by Aberrant PI3K in Cancer

Constitutive Signaling by Aberrant PI3K in Cancer

http://www.wikidata.org/entity/Q45314384

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PI3K gain of function mutants phosphorylate PIP2 to PIP3 PI3K inhibitors block PI3K catalytic activity

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PI3K/AKT Signaling in Cancer

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Constitutive Signaling by Aberrant PI3K in Cancer

http://www.wikidata.org/entity/Q45314384

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An instance of the biological ...... PI3K in Cancer in Homo sapiens

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name

Constitutive Signaling by Aberrant PI3K in Cancer

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type

label

Constitutive Signaling by Aberrant PI3K in Cancer

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Constitutive Signaling by Aberrant PI3K in Cancer

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Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells.

PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.

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reactome:R-HSA-2219530

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biological pathway

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PI3K/AKT Signaling in Cancer

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R-HSA-2219530

http://www.w3.org/2001/XMLSchema#string

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PI3K gain of function mutants phosphorylate PIP2 to PIP3

PI3K inhibitors block PI3K catalytic activity

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