about
C3 convertases spontaneously dissociateFactor H binds to C3bFactor H binds host cell surface markersFactor H binds to membrane-associated C3bFactor H binds to C3bBbFactor H displaces BbCFHR dimers bind C3bComplement factor I complex formationComplement factor I binds to extracellular Factor H:C3bFactor I inactivates plasma Factor H-bound C3bComplement factor I binds to membrane-associated Factor H:C3bFactor I inactivates Factor H-boundC3bFactor I cleaves iC3bCR1 binds C3bBb/C4bC2aDisplacement of C2a/Bb by CR1CR2 binds C3d; C3dg; iC3bCR2:C3d;C3dg;iC3b binds CD19:CD81CD46 binds C3bCD46 binds C4bComplement factor I binds to MCP; CR1:C4b; C3bFactor I inactivates MCP/CR1-bound C4b/C3bCD55 (DAF) binds C3bBb; C4bC2aCD55 (DAF) promotes C3bBb/C4bC2a dissociationC4b-binding protein binds C4bComplement factor I binds C4BPComplement factor I inactivates C4BP-bound C4bC4b binding protein binds C4bC2aC4b binding protein displaces C2aC4b binding protein binds Protein SCD59 inhibits MAC formationFormation of soluble VTN:C5b-C9Vitronectin (VTN) binds to C5b:C6:C7Hydrolysis of internal thioester in C4bC1-Inh binds Antigen: antibody: C1 complex activated C1r; C1sAntigen:IgG:C1Q:2xActivated C1R:SERPING1:2xActivated C1S:SERPING1 dissociatesC3a receptor binds anaphylatoxin C3aC5a receptor binds C5a anaphylatoxinC5AR2 binds anaphylatoxins and thier desArginated derivativesClusterin binds C5b-C7; C8; C9Thrombin; ELANE cleave C5
P361
Q50291896-0F184A49-860C-4B79-9F19-6E614DFB6DD3Q50291897-EB024535-52B0-446E-BA56-7BF3E13DC8A8Q50291898-A1E78230-3E36-495B-83AB-ADD6F12667ACQ50291900-E204BA47-5E03-4A96-AB2C-7F85EC194A09Q50291902-63D0FB5D-12AA-467B-9EBC-81D779793E63Q50291903-D21C8C1B-6017-4700-AB1C-0366664979B5Q50291904-C7471B10-C7C4-4025-AA57-2469C52CD0A6Q50291905-9810CB5E-E71E-40D2-92B5-F2F89EF9401FQ50291906-AFDB60C4-CB16-4D55-98C3-FB74406FF08FQ50291907-87BC4F8E-619B-4076-A527-4BAB374E72F2Q50291909-FDA7F933-B9E4-4F28-87CB-4431894959C3Q50291910-8199DE4E-FB86-4EEE-B712-5C3CE7F35F34Q50291911-38C4AEB4-71C9-4A73-B4F7-B2BD5CC23C18Q50291912-FB0B0FE9-7ECD-46A0-81FC-562CAEF74103Q50291913-6CDD1159-6528-4548-948B-6807D49D649EQ50291914-71168EB6-F816-45F9-B928-5A3788BFB6E0Q50291915-730A301A-AE32-4B9B-BC9B-95523496A227Q50291917-E1614B4D-67E9-4EA6-803A-E9255850041BQ50291918-DBBD01DB-D6DC-4E82-AD46-4F8EA75E3356Q50291919-9DDFE79B-B531-42E2-A3FF-04B413C9BBBEQ50291921-39E6C32C-29C0-498E-8E9F-2D01DB969140Q50291922-B7FCAC5E-D253-4BFA-9044-DF8B3F9795A2Q50291923-C7C1A097-0E5D-4B23-BFF7-3795318FAC70Q50291924-D26A40AE-F1BF-40D2-8786-FFD1468A2815Q50291926-CD5D197B-60F6-4B6B-9FFE-F72D13BD6624Q50291927-1FFBF8B5-3503-4EB2-AC8A-C60DCB2CB615Q50291928-2FB04ECF-3830-4475-9360-070443302878Q50291929-8F8BEE1A-889C-4394-859B-7C1DBA9655C6Q50291930-F90DDD77-655C-43C4-93B8-CDA3CB41CD51Q50291931-38019905-E481-44D5-B872-B91FA8E26733Q50291932-A2F48C32-7E3C-4440-8C30-BF62291C0CC2Q50291933-D34D2EA4-E541-49C4-B564-CD8073571351Q50291934-94D6F100-D8C3-48C8-AE63-CB3E4F0C0EBEQ50291936-D92184D6-21CD-4538-A0E1-C944483C6280Q50291937-A991C955-9D02-468C-B89B-EED3595C793BQ50291938-19327F3B-BA1F-4BA5-A8BB-EEAF78F241B0Q50291939-23240298-6D85-4AE6-A753-3254ACCDA01CQ50291940-C441EDD4-048E-466B-B252-50D4DDA689DAQ50291942-51E6DA95-CF6B-4868-9FE9-9CBC1599334AQ50291943-657F7A04-CB38-4EC4-845D-AB655B203156
P361
description
An instance of the biological pathway Regulation of Complement cascade in Homo sapiens
@en
name
Regulation of Complement cascade
@en
type
label
Regulation of Complement cascade
@en
prefLabel
Regulation of Complement cascade
@en
P2860
P527
P2860
P3937
R-HSA-977606