about
Regulation of signaling by CBLThe common beta chain IL3RB binds JAK2GM-CSF receptor alpha subunit binds GM-CSFGM-CSF receptor alpha:GM-CSF binds BcInterleukin-5 is a homodimerInterleukin-5 receptor alpha subunit binds Interleukin-5Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2Interleukin-3 receptor alpha subunit binds Interleukin-3Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2The receptor is activatedJAK2 is phosphorylated; activatedSTAT5 is recruited by JAK2Activation of STAT5a/b by JAK2p-STAT5 dissociates from the receptor complexTyrosine kinases phosphorylate the receptorRecruitment of SHC1 is mediated by Y593 of the common beta chainSHC1 bound to the common beta chain becomes tyrosine phosphorylatedIL3 stimulation induces Vav binding to Tec kinaseSHP1 and SHP2 bind the common beta chainSHP1 and SHP2 dephosphorylate Y628 of IL3RBSHP2 can recruit GRB2IL3RB is phosphorylated on Ser-585p-S585-IL3RB binds 14-3-3 proteins14-3-3 zeta binding allows recruitment of PI3K
P361
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description
An instance of the biological ...... -CSF signaling in Homo sapiens
@en
name
Interleukin-3, Interleukin-5 and GM-CSF signaling
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type
label
Interleukin-3, Interleukin-5 and GM-CSF signaling
@en
prefLabel
Interleukin-3, Interleukin-5 and GM-CSF signaling
@en
P527
P2860
P3937
R-HSA-512988