about
SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosolSLC36A4 transports L-Trp from extracellular region to cytosolTDO tetramer dioxygenates L-Trp to NFKIDO1 dioxygenates L-Trp to NFKIDO2 dioxygenates L-Trp to NFKAFMID hydrolyses NFK to L-KYNPXLP-KYAT1 dimer transaminates L-KYN to AP-DOBukynurenine + pyruvate => 4-(2-aminophenyl)-2;4-dioxobutanoic acid + alanine4-(2-aminophenyl)-2;4-dioxobutanoate => kynurenic acid + H2Okynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO22-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2;4-dioxobutanoic acid + glutamate4-(2-aminophenyl)-2;4-dioxobutanoate => kynurenic acid + H2O [mitochondrial]
P361
Q50295044-DC42CCBA-327C-4CBB-822A-5B9F344C4C02Q50295045-E55B7EDD-722D-4729-9EB8-5580AD965277Q50295046-968B35AE-0DAC-4E64-9B11-79383159B8DCQ50295047-2A961841-DCFA-487F-A8E8-0A92783BD994Q50295048-BDE99178-8DD8-453E-9836-390AC69A62D0Q50295049-3DF8952C-97F6-4C24-B303-5BB099463703Q50295051-F2C65AC8-E112-4A99-8204-F219303870E9Q50295052-2B12D342-E4C2-45E2-83BC-B8FB5A853139Q50295053-64BD0BA5-A745-4E03-B194-3719E8735A1AQ50295055-1667F27D-687A-420C-BD2D-50F1FC6D8699Q50295056-DFADDBFB-9387-4D2A-8A7F-4BD933585BCAQ50295057-ECB2D2F3-9EFF-4DDE-8B44-FF09D15D1564Q50295059-E953A8FE-3335-4E1E-892E-B97857A8EF79Q50295060-4676E997-5B66-4382-A25B-BE723649EB95Q50295061-E7708821-F5A2-40F0-AF68-2E08DEAA0375Q50295062-339A1951-6966-4701-96E3-7A20A2F0E16B
P361
description
An instance of the biological pathway Tryptophan catabolism in Homo sapiens
@en
name
Tryptophan catabolism
@en
type
label
Tryptophan catabolism
@en
prefLabel
Tryptophan catabolism
@en
P527
P2888
P3937
R-HSA-71240