about
Binding of CBL to EGFRPhosphorylation of CBL (EGFR:CBL)CBL binds and ubiquitinates phosphorylated SproutyUbiquitination of stimulated EGFR (CBL)CBL binds to GRB2Localization of CBL:GRB2 to the membranePhosphorylation of CBL (EGFR:GRB2:CBL)Ubiquitination of stimulated EGFR (CBL:GRB2)Sprouty lures CBL away from EGFRSprouty lures membrane-bound CBL away from EGFRCDC42:GTP binds CBL:Beta-PixBeta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-PixAssembly of EGFR complex in clathrin-coated vesiclesEGFR non-clathrin mediated endocytosisCBL ubiquitinates SproutyCBL-mediated ubiquitination of CIN85Sprouty sequesters CBL away from active EGFRPTPN12 dephosphorylates EGFR at Y1148 (Y1172)EGFR binds EPS15; EPN1; EPS15L1EGFR phosphorylates EPS15PTPN3 dephosphorylates EPS15
P361
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P361
description
An instance of the biological pathway EGFR downregulation in Homo sapiens
@en
name
EGFR downregulation
@en
type
label
EGFR downregulation
@en
prefLabel
EGFR downregulation
@en
P2860
P527
P2860
P3937
R-HSA-182971