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Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation.RasGRP1 is required for human NK cell functionClinical perspectives on lupus genetics: advances and opportunitiesRapid encoding of new information alters the profile of plasticity-related mRNA transcripts in the hippocampal CA3 regionHistone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cellsInduction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation.The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.Function of RasGRP3 in the formation and progression of human breast cancerResponse and resistance to MEK inhibition in leukaemias initiated by hyperactive RasBasal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expressionRasGRP3 contributes to formation and maintenance of the prostate cancer phenotype.Phosphoinositide 3-kinase regulates plasma membrane targeting of the Ras-specific exchange factor RasGRP1.RasGRP3 regulates the migration of glioma cells via interaction with Arp3Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesionWealth of opportunity - the C1 domain as a target for drug development.The genetics of lupus: a functional perspective.Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors.Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.Tegumentary manifestations of Noonan and Noonan-related syndromes.RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factorA proapoptotic signaling pathway involving RasGRP, Erk, and Bim in B cells.RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.The coordination of T-cell function by serine/threonine kinases.G alpha i2 and ZAP-70 mediate RasGRP1 membrane localization and activation of SDF-1-induced T cell functions.TLR2 signaling subpathways regulate TLR9 signaling for the effective induction of IL-12 upon stimulation by heat-killed Brucella abortus.Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis.Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesisRasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.RasGRP1 Is an Essential Signaling Molecule for Development of B1a Cells with Autoantigen ReceptorsGene Network Construction from Microarray Data Identifies a Key Network Module and Several Candidate Hub Genes in Age-Associated Spatial Learning Impairment.A RasGRP, C. elegans RGEF-1b, couples external stimuli to behavior by activating LET-60 (Ras) in sensory neurons.Signaling by the B Cell Receptor (BCR)Downstream signaling events of B Cell Receptor (BCR)Getting a GRP on histone deacetylase inhibitor selectivity.Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP.Autoimmune disease and multiple autoantibodies in 42 patients with RASopathies
P2860
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P2860
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Regulation of Ras in lymphocytes: get a GRP.
@en
Regulation of Ras in lymphocytes: get a GRP.
@nl
type
label
Regulation of Ras in lymphocytes: get a GRP.
@en
Regulation of Ras in lymphocytes: get a GRP.
@nl
prefLabel
Regulation of Ras in lymphocytes: get a GRP.
@en
Regulation of Ras in lymphocytes: get a GRP.
@nl
P356
P1476
Regulation of Ras in lymphocytes: get a GRP.
@en
P2093
P304
P356
10.1042/BST0340858
P577
2006-11-01T00:00:00Z