The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. - Wikidata - wikimedia - TriplyDB

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

http://www.wikidata.org/entity/Q45375299

about

Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Histone demethylase LSD1 controls the phenotypic plasticity of cancer cells Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Epigenetic regulators and their impact on therapy in acute myeloid leukemia Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting Mechanisms of epigenetic regulation of leukemia onset and progression Recent progress toward epigenetic therapies: the example of mixed lineage leukemia The role of histone demethylases in cancer therapy Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia Childhood acute myeloid leukaemia The double PHD finger domain of MOZ/MYST3 induces -helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification Emerging concepts of epigenetic dysregulation in hematological malignancies KDM1 class flavin-dependent protein lysine demethylases LSD1 inhibition: a therapeutic strategy in cancer?Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16 Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia.Identification of JL1037 as a novel, specific, reversible lysine-specific demethylase 1 inhibitor that induce apoptosis and autophagy of AML cells Chromatin proteins and modifications as drug targets.C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4.Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.The epigenetics of epithelial-mesenchymal plasticity in cancer.Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma.Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells Targeting histone lysine demethylases - progress, challenges, and the future Epigenetic drugs against cancer: an evolving landscape.PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D.Small-molecular modulators of cancer-associated epigenetic mechanisms.Concise review: preleukemic stem cells: molecular biology and clinical implications of the precursors to leukemia stem cells Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.LSD1: biologic roles and therapeutic targeting.The progenitor state is maintained by lysine-specific demethylase 1-mediated epigenetic plasticity during Drosophila follicle cell development.Suppression of gluconeogenic gene expression by LSD1-mediated histone demethylation.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies.Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.

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The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells.

http://www.wikidata.org/entity/Q45375299

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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name

The histone demethylase KDM1A ...... f MLL-AF9 leukemia stem cells.

@en

The histone demethylase KDM1A ...... f MLL-AF9 leukemia stem cells.

@nl

type

label

The histone demethylase KDM1A ...... f MLL-AF9 leukemia stem cells.

@en

The histone demethylase KDM1A ...... f MLL-AF9 leukemia stem cells.

@nl

prefLabel

The histone demethylase KDM1A ...... f MLL-AF9 leukemia stem cells.

@en

The histone demethylase KDM1A ...... f MLL-AF9 leukemia stem cells.

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J.CCR.2012.03.014

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The histone demethylase KDM1A ...... f MLL-AF9 leukemia stem cells.

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Allan M Jordan

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Brigit F Greystoke

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Donald J Ogilvie

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Filippo Ciceri

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Gary J Spencer

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James R Hitchin

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James T Lynch

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Julian G Blaser

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Tim C P Somervaille

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William J Harris

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473-487

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scholarly article

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10.1016/J.CCR.2012.03.014

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Crispin J. Miller

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