Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.
about
A motif unique to the human DEAD-box protein DDX3 is important for nucleic acid binding, ATP hydrolysis, RNA/DNA unwinding and HIV-1 replicationDDX3, a potential target for cancer treatmentEvolutionary constraints acting on DDX3X protein potentially interferes with Rev-mediated nuclear export of HIV-1 RNA.The PDZ-ligand and Src-homology type 3 domains of epidemic avian influenza virus NS1 protein modulate human Src kinase activity during viral infection.RNA helicases in infection and disease.New in silico and conventional in vitro approaches to advance HIV drug discovery and design.Expression of the RNA helicase DDX3 and the hypoxia response in breast cancerKetorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer.Identification of RNA helicases in human immunodeficiency virus 1 (HIV-1) replication - a targeted small interfering RNA library screen using pseudotyped and WT HIV-1Discovering new medicines targeting helicases: challenges and recent progress.Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studiesNZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3.Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.PLGA nanoparticle formulation of RK-33: an RNA helicase inhibitor against DDX3In vitro anti-cancer activity of doxorubicin against human RNA helicase, DDX3.Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?The Ded1/DDX3 subfamily of DEAD-box RNA helicases.Multiple functions of DDX3 RNA helicase in gene regulation, tumorigenesis, and viral infection.Synthetic Development of New 3-(4-Arylmethylamino)butyl-5-arylidene-rhodanines under Microwave Irradiation and Their Effects on Tumor Cell Lines and against Protein Kinases.Wanted DEAD/H or Alive: Helicases Winding Up in Cancers.Identification of RNA-protein interaction networks involved in the norovirus life cycle.Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.Targeting RNA helicases in cancer: The translation trap.Recent developments with rhodanine as a scaffold for drug discovery.MOLIERE: Automatic Biomedical Hypothesis Generation System.Thiopyrano[2,3-d]Thiazoles as New Efficient Scaffolds in Medicinal Chemistry.New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy
P2860
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P2860
Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh-hant
name
Pharmacophore modeling and mol ...... partic acid box polypeptide 3.
@en
Pharmacophore modeling and mol ...... partic acid box polypeptide 3.
@nl
type
label
Pharmacophore modeling and mol ...... partic acid box polypeptide 3.
@en
Pharmacophore modeling and mol ...... partic acid box polypeptide 3.
@nl
prefLabel
Pharmacophore modeling and mol ...... partic acid box polypeptide 3.
@en
Pharmacophore modeling and mol ...... partic acid box polypeptide 3.
@nl
P2093
P356
P1476
Pharmacophore modeling and mol ...... partic acid box polypeptide 3.
@en
P2093
Amalia Belfiore
Anna Garbelli
Giovanni Maga
Maurizio Botta
Myriam Witvrouw
P304
P356
10.1021/JM8008844
P407
P577
2008-10-04T00:00:00Z