The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
about
HIV type 1 Gag as a target for antiviral therapyVirus maturation as a new HIV-1 therapeutic targetNew insights into HTLV-1 particle structure, assembly, and Gag-Gag interactions in living cellsThe choreography of HIV-1 proteolytic processing and virion assemblyEbselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication.Domain-swapped dimerization of the HIV-1 capsid C-terminal domainFlexibility in HIV-1 Assembly Subunits: Solution Structure of the Monomeric C-Terminal Domain of the Capsid ProteinStructure of the Antiviral Assembly Inhibitor CAP-1 Complex with the HIV-1 CA ProteinSolution Structure of a Hydrocarbon Stapled Peptide Inhibitor in Complex with Monomeric C-terminal Domain of HIV-1 CapsidResidues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid proteinX-ray structures of the hexameric building block of the HIV capsid.Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid FunctionLimitations of Peptide Retro-inverso Isomerization in Molecular MimicryHIV Capsid is a Tractable Target for Small Molecule Therapeutic InterventionAtomic-level modelling of the HIV capsidCPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 ReplicationStructure of a Monomeric Mutant of the HIV-1 Capsid ProteinA triclinic crystal structure of the carboxy-terminal domain of HIV-1 capsid protein with four molecules in the asymmetric unit reveals a novel packing interfaceDistinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA ProteinDiscovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid ComplexesStructure of the immature retroviral capsid at 8 Å resolution by cryo-electron microscopyMonitoring binding of HIV-1 capsid assembly inhibitors using (19)F ligand-and (15)N protein-based NMR and X-ray crystallography: early hit validation of a benzodiazepine seriesRationally designed interfacial peptides are efficient in vitro inhibitors of HIV-1 capsid assembly with antiviral activityCharacterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assayMolecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor NefLarge-scale functional purification of recombinant HIV-1 capsidSTRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.Could the Ebola virus matrix protein VP40 be a drug target?MAS NMR of HIV-1 protein assemblies.Design of in vitro symmetric complexes and analysis by hybrid methods reveal mechanisms of HIV capsid assemblyThe structural biology of HIV assembly.Surveying capsid assembly pathways through simulation-based data fitting.Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interactionA peptide inhibitor of HIV-1 assembly in vitro.A cell-penetrating helical peptide as a potential HIV-1 inhibitor.The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly.A simple fluorescence based assay for quantification of human immunodeficiency virus particle releaseNovel approaches to inhibiting HIV-1 replication.Virtual screening based identification of novel small-molecule inhibitors targeted to the HIV-1 capsid.Anti-HIV-1 therapeutics: from FDA-approved drugs to hypothetical future targets
P2860
Q24614498-F42CA037-3B82-4C86-BD58-8F2DC0AFBD13Q24642446-100E3B3E-FAAB-4BD9-AB91-DF2DD4F88774Q26851321-B737D5C8-CAD3-4B76-89B5-BFD2A9A07BD4Q27009643-D92D99B9-3466-4A25-B5FD-5C182060C75FQ27324193-41A52359-E780-4C19-8B9A-7C980604C537Q27644067-D585B5B0-D852-45E5-86A3-1B1FA684D605Q27644938-FD5726D4-1543-4E11-87F7-5EFE5FC3F056Q27647971-0C886F14-3F27-44B3-A274-B67116FED2A1Q27650342-EA556460-0B0A-474A-8027-E32F8A1997EEQ27651983-14D67F8C-B1B8-4531-AD3F-A6660AFF0267Q27655910-DCF0E607-236B-4F40-953B-E92F6E9A57F3Q27658179-4B5CDBDC-1286-4801-9A94-394FEC2CD1E1Q27660480-889C786E-2F58-4EA4-B08E-A15C879E33BCQ27666355-39D0F6F7-C81E-411D-B92F-5A3C5327FF01Q27666657-B3A2703C-FFDC-4B2E-8A26-18B9149EF6C2Q27672646-52CA71CB-8236-4FAD-AA69-C89C86EEA068Q27675009-8DF954FB-3415-4520-A2CC-E4CCEE0EDE14Q27678401-6AA2C412-4EE7-4122-ACFB-205D4DA62507Q27678471-88D74B87-ECE3-4771-94AC-9FC620BACB42Q27678859-98557A2F-7D3A-4CA5-9E68-E09907FC251FQ27681296-A4D7B732-FA95-4B56-B75D-D7E4CDAE9467Q27683977-B821EF2E-B2A8-4CCB-8055-72C88ADE6DB2Q28476840-C4D44822-5BD6-46CE-AE8C-F65F5276D770Q28477791-A265DAE7-BE81-4074-837A-F949241D2FE5Q28478210-9A562EB9-6B3D-4061-848F-ECDCF1F7BDAFQ28487670-285C0017-574E-4B71-9195-356F88F97515Q30279235-E5A65F0F-F9ED-4AB0-ADAC-9615E21C535CQ30356113-F602858F-7BC7-47AE-B760-30DA72F81F41Q30372916-CDECEBAA-2DB2-4D1C-8C04-8A3A55EE29E4Q30425900-66441F80-BB10-40E6-BB8C-5C1286A40315Q30437103-2BC51AC4-FE38-4052-97C0-1D9A9791D2EFQ30573237-E3725C11-2A2C-4FFC-B84D-9921331CC2C3Q31046491-64264556-ACBD-4F3F-A5C9-51CB7E11DECDQ33220259-1E3B1D96-C3F2-419E-BD92-10FEAA6E5856Q33326188-32429695-4C37-496A-A25C-F3217E59F5C4Q33510254-70B6C3D3-AC91-4AC7-BB9C-39A917FA811AQ33560406-11436BB4-16CD-4375-B6BD-737FC65579A9Q33624690-5CB4BFCE-2663-4BA5-8C1D-497E2B71AA96Q33774977-6FE5460E-D124-4B32-B5B3-5EDDB9D5DD12Q33819240-04CEEA03-8DB7-4B47-8E73-DBF5DD701EC5
P2860
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
@en
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
@nl
type
label
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
@en
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
@nl
prefLabel
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
@en
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
@nl
P2860
P50
P356
P1476
The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor.
@en
P2093
François Ternois
Jana Sticht
P2860
P2888
P304
P356
10.1038/NSMB967
P577
2005-07-24T00:00:00Z
P5875
P6179
1001565920