Catalytic mechanism of heme oxygenase through EPR and ENDOR of cryoreduced oxy-heme oxygenase and its Asp 140 mutants.
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Characterization of the peroxidase mechanism upon reaction of prostacyclin synthase with peracetic acid. Identification of a tyrosyl radical intermediateCrystal structure of rat heme oxygenase-1 in complex with heme bound to azide. Implication for regiospecific hydroxylation of heme at the alpha-meso carbonThe crystal structures of the ferric and ferrous forms of the heme complex of HmuO, a heme oxygenase of Corynebacterium diphtheriaeCrystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase functionDistinct reaction pathways followed upon reduction of oxy-heme oxygenase and oxy-myoglobin as characterized by Mössbauer spectroscopy.Solution 1H NMR investigation of the active site molecular and electronic structures of substrate-bound, cyanide-inhibited HmuO, a bacterial heme oxygenase from Corynebacterium diphtheriae.1H NMR investigation of the solution structure of substrate-free human heme oxygenase: comparison to the cyanide-inhibited, substrate-bound complex.Characterization of an Fe≡N-NH2 Intermediate Relevant to Catalytic N2 Reduction to NH3.1H NMR study of the magnetic properties and electronic structure of the hydroxide complex of substrate-bound heme oxygenase from Neisseria meningitidis: influence of the axial water deprotonation on the distal H-bond network.Connecting nitrogenase intermediates with the kinetic scheme for N2 reduction by a relaxation protocol and identification of the N2 binding state.Reaction mechanisms of 15-hydroperoxyeicosatetraenoic acid catalyzed by human prostacyclin and thromboxane synthases.Electron-nuclear double resonance spectroscopy (and electron spin-echo envelope modulation spectroscopy) in bioinorganic chemistry.The role of copper and protons in heme-copper oxidases: kinetic study of an engineered heme-copper center in myoglobin.Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450.Models and mechanisms of O-O bond activation by cytochrome P450. A critical assessment of the potential role of multiple active intermediates in oxidative catalysis.The ferric-hydroperoxo complex of chloroperoxidaseCompound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies.Evidence That Compound I Is the Active Species in Both the Hydroxylase and Lyase Steps by Which P450scc Converts Cholesterol to Pregnenolone: EPR/ENDOR/Cryoreduction/Annealing StudiesComparison of the Mechanisms of Heme Hydroxylation by Heme Oxygenases-1 and -2: Kinetic and Cryoreduction StudiesSpectroscopic and Crystallographic Evidence for the Role of a Water-Containing H-Bond Network in Oxidase Activity of an Engineered Myoglobin.The use of deuterated camphor as a substrate in (1)H ENDOR studies of hydroxylation by cryoreduced oxy P450cam provides new evidence of the involvement of compound IAlteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding networkReaction of the Co(II)-substrate radical pair catalytic intermediate in coenzyme B12-dependent ethanolamine ammonia-lyase in frozen aqueous solution from 190 to 217 KResonance Raman spectroscopic studies of hydroperoxo derivatives of cobalt-substituted myoglobin.Active intermediates in heme monooxygenase reactions as revealed by cryoreduction/annealing, EPR/ENDOR studies.Using Biosynthetic Models of Heme-Copper Oxidase and Nitric Oxide Reductase in Myoglobin to Elucidate Structural Features Responsible for Enzymatic Activities.Spectroscopic studies of the cytochrome P450 reaction mechanisms.Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron-Nuclear Double Resonance Spectroscopy.Cysteine 98 in CYP3A4 contributes to conformational integrity required for P450 interaction with CYP reductase.Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism.Heme utilization by pathogenic bacteria: not all pathways lead to biliverdin.Electron paramagnetic resonance and electron-nuclear double resonance studies of the reactions of cryogenerated hydroperoxoferric-hemoprotein intermediates.Probing the oxyferrous and catalytically active ferryl states of Amphitrite ornata dehaloperoxidase by cryoreduction and EPR/ENDOR spectroscopy. Detection of compound I.Probing the ternary complexes of indoleamine and tryptophan 2,3-dioxygenases by cryoreduction EPR and ENDOR spectroscopyCryoradiolytic reduction of heme proteins: Maximizing dose dependent yield.Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes p450.Structure and reactivity of a thermostable prokaryotic nitric-oxide synthase that forms a long-lived oxy-heme complex.Characterization of the microsomal cytochrome P450 2B4 O2 activation intermediates by cryoreduction and electron paramagnetic resonance.Unique features of recombinant heme oxygenase of Drosophila melanogaster compared with those of other heme oxygenases studied.Human heme oxygenase oxidation of 5- and 15-phenylhemes.
P2860
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P2860
Catalytic mechanism of heme oxygenase through EPR and ENDOR of cryoreduced oxy-heme oxygenase and its Asp 140 mutants.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Catalytic mechanism of heme ox ...... enase and its Asp 140 mutants.
@en
Catalytic mechanism of heme ox ...... enase and its Asp 140 mutants.
@nl
type
label
Catalytic mechanism of heme ox ...... enase and its Asp 140 mutants.
@en
Catalytic mechanism of heme ox ...... enase and its Asp 140 mutants.
@nl
prefLabel
Catalytic mechanism of heme ox ...... enase and its Asp 140 mutants.
@en
Catalytic mechanism of heme ox ...... enase and its Asp 140 mutants.
@nl
P2093
P356
P1476
Catalytic mechanism of heme ox ...... enase and its Asp 140 mutants.
@en
P2093
Brian M Hoffman
Hiroshi Fujii
Masao Ikeda-Saito
Roman Davydov
Tadashi Yoshida
Viktoria Kofman
P304
P356
10.1021/JA0122391
P407
P577
2002-02-01T00:00:00Z