Targeting p53 by small molecule p53 activators in multiple myeloma.

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Targeting p53 by small molecule p53 activators in multiple myeloma.

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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Targeting p53 by small molecule p53 activators in multiple myeloma.

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Targeting p53 by small molecule p53 activators in multiple myeloma.

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Targeting p53 by small molecule p53 activators in multiple myeloma.

@en

Targeting p53 by small molecule p53 activators in multiple myeloma.

@nl

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Targeting p53 by small molecule p53 activators in multiple myeloma.

@en

Targeting p53 by small molecule p53 activators in multiple myeloma.

@nl

P1476

Targeting p53 by small molecule p53 activators in multiple myeloma

@en

P2093

Hong Chang

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Manujendra N Saha

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Yijun Yang

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P2860

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

The MDM2-p53 interaction.

Translating p53 into the clinic.

Reactivation of p53: from peptides to small molecules.

Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.

MDM2 antagonist nutlin plus proteasome inhibitor velcade combination displays a synergistic anti-myeloma activity.

RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses.

p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation.

P304

A7-A7

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P31

scholarly article

P356

10.1186/1756-8722-5-S1-A7

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P433

Suppl 1

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P478

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P577

2012-04-25T00:00:00Z

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P932

3337260

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