Immune tolerance induced by platelet-targeted factor VIII gene therapy in hemophilia A mice is CD4 T cell mediated.

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Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A.Platelet-Targeted Gene Therapy for Hemophilia.Platelet Gene Therapy Promotes Targeted Peripheral Tolerance by Clonal Deletion and Induction of Antigen-Specific Regulatory T Cells

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Immune tolerance induced by platelet-targeted factor VIII gene therapy in hemophilia A mice is CD4 T cell mediated.

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Immune tolerance induced by pl ...... A mice is CD4 T cell mediated.

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Immune tolerance induced by pl ...... A mice is CD4 T cell mediated.

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Immune tolerance induced by pl ...... A mice is CD4 T cell mediated.

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Immune tolerance induced by pl ...... A mice is CD4 T cell mediated.

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Immune tolerance induced by pl ...... A mice is CD4 T cell mediated.

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Immune tolerance induced by pl ...... A mice is CD4 T cell mediated.

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Immune tolerance induced by pl ...... A mice is CD4 T cell mediated.

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C K Baumgartner

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J A Schroeder

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J Chen

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J Hu

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Q Shi

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X Luo

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Y Chen

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The use of concanavalin A to study the immunoregulation of human T cells

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

How regulatory T cells work

Regulatory T cells and immune tolerance

Influence of sublethal total-body irradiation on immune cell populations in the intestinal mucosa

In vivo enrichment of genetically manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infection

Transient B cell depletion or improved transgene expression by codon optimization promote tolerance to factor VIII in gene therapy.

The contributions of T-cell anergy to peripheral T-cell tolerance.

Suppressor T cells--they're back and critical for regulation of autoimmunity!

Lentivirus-mediated platelet-derived factor VIII gene therapy in murine haemophilia A.

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1994-2004

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scholarly article

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10.1111/JTH.13800

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hemophilia

hemophilia A

gene therapy

Coagulation factor VIII

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Immune tolerance induced by platelet-targeted factor VIII gene therapy in hemophilia A mice is CD4 T cell mediated.

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P2860

P2860

Immune tolerance induced by platelet-targeted factor VIII gene therapy in hemophilia A mice is CD4 T cell mediated.

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