about
Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoproteinCorrection of the ion transport defect in cystic fibrosis transgenic mice by gene therapyIdentification and functional characterization of cytoplasmic determinants of plasmid DNA nuclear import.The use of carboxymethylcellulose gel to increase non-viral gene transfer in mouse airways.Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial.Inefficient cationic lipid-mediated siRNA and antisense oligonucleotide transfer to airway epithelial cells in vivo.Assessment of F/HN-pseudotyped lentivirus as a clinically relevant vector for lung gene therapyIdentification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA.Lack of repeat transduction by recombinant adeno-associated virus type 5/5 vectors in the mouse airwayA Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose TrialCpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression.Progress and prospects: the design and production of plasmid vectors.Self-reactive CFTR T cells in humans: implications for gene therapy.Strategies for long-term expression of transgenes in the respiratory epithelium.Delivery of genes into the CF airway.Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.Limitations of the murine nose in the development of nonviral airway gene transfer.Optimizing aerosol gene delivery and expression in the ovine lung.Human-specific cystic fibrosis transmembrane conductance regulator antibodies detect in vivo gene transfer to ovine airways.Keratinocyte growth factor therapy in murine oleic acid-induced acute lung injury.Efficient in vivo transfection and safety profile of a CpG-free and codon optimized luciferase plasmid using a cationic lipophosphoramidate in a multiple intravenous administration procedure.Assessment of CFTR function after gene transfer in vitro and in vivo.Tamoxifen blocks chloride channels. A possible mechanism for cataract formation.Increased persistence of lung gene expression using plasmids containing the ubiquitin C or elongation factor 1alpha promoter.Identification of transfected cell types following non-viral gene transfer to the murine lung.Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung.Clinical improvement in cystic fibrosis following anti-tumourous chemotherapy.The use of CpG-free plasmids to mediate persistent gene expression following repeated aerosol delivery of pDNA/PEI complexes.Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer.Sendai virus-mediated CFTR gene transfer to the airway epithelium.The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep.A novel mixing device for the reproducible generation of nonviral gene therapy formulations.Effects of a novel archaeal tetraether-based colipid on the in vivo gene transfer activity of two cationic amphiphiles.The significance of plasmid DNA preparations contaminated with bacterial genomic DNA on inflammatory responses following delivery of lipoplexes to the murine lung.Ignoring the nonsense: a phase II trial in cystic fibrosis.CpG-free plasmid expression cassettes for cystic fibrosis gene therapy.Rapid identification of novel functional promoters for gene therapy.A placebo-controlled study of liposome-mediated gene transfer to the nasal epithelium of patients with cystic fibrosis.Detection of plasmid DNA vectors following gene transfer to the murine airways.Temporal regulation of CFTR expression during ovine lung development: implications for CF gene therapy.
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description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Stephen C Hyde
@ast
Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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type
label
Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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prefLabel
Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
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Stephen C Hyde
@en
Stephen C Hyde
@es
Stephen C Hyde
@fr
Stephen C Hyde
@nl
Stephen C Hyde
@sl
P106
P21
P31
P496
0000-0002-8877-4005