Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
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Theiler's virus infection: a model for multiple sclerosisInfection as an Environmental Trigger of Multiple Sclerosis Disease ExacerbationTheiler's virus infection induces a predominant pathogenic CD4+ T cell response to RNA polymerase in susceptible SJL/J micePredominant clonal accumulation of CD8+ T cells with moderate avidity in the central nervous systems of Theiler's virus-infected C57BL/6 mice.Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosisQuantitative assessment of neurologic deficits in a chronic progressive murine model of CNS demyelination.Absence of spontaneous central nervous system remyelination in class II-deficient mice infected with Theiler's virus.Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus.Quantitation of spinal cord demyelination, remyelination, atrophy, and axonal loss in a model of progressive neurologic injury.Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis.Characterization of and functional antigen presentation by central nervous system mononuclear cells from mice infected with Theiler's murine encephalomyelitis virusRole of individual T-cell epitopes of Theiler's virus in the pathogenesis of demyelination correlates with the ability to induce a Th1 response.Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected miceCD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease.Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1.Interleukin-6 (IL-6) and IL-17 synergistically promote viral persistence by inhibiting cellular apoptosis and cytotoxic T cell functionA spontaneous low-pathogenic variant of Theiler's virus contains an amino acid substitution within the predominant VP1(233-250) T-cell epitope.Susceptibility of inbred mice to chronic central nervous system infection by Theiler's murine encephalomyelitis virus.Capsid-specific cytotoxic T lymphocytes recognize three distinct H-2D(b)-restricted regions of the BeAn strain of Theiler's virus and exhibit different cytokine profilesThe majority of infiltrating CD8+ T cells in the central nervous system of susceptible SJL/J mice infected with Theiler's virus are virus specific and fully functional.Contrasting effects of immunosuppression on Theiler's virus infection in miceCD154 blockade results in transient reduction in Theiler's murine encephalomyelitis virus-induced demyelinating disease.Preferential induction of protective T cell responses to Theiler's virus in resistant (C57BL/6 x SJL)F1 miceThe level of viral infection of antigen-presenting cells correlates with the level of development of Theiler's murine encephalomyelitis virus-induced demyelinating disease.Anandamide inhibits Theiler's virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB(1) receptorsNeurotropic viral infections leading to epilepsy: focus on Theiler's murine encephalomyelitis virusQuantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosisIRF3 deficiency impacts granzyme B expression and maintenance of memory T cell function in response to viral infection.TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infectionThe leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells.A Sativex(®) -like combination of phytocannabinoids as a disease-modifying therapy in a viral model of multiple sclerosis.Role of macrophages during Theiler's virus infection.The shiverer mutation affects the persistence of Theiler's virus in the central nervous systemHippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infectionIL-1 signal affects both protection and pathogenesis of virus-induced chronic CNS demyelinating disease.Differential virus replication, cytokine production, and antigen-presenting function by microglia from susceptible and resistant mice infected with Theiler's virusAnalysis of antibody responses to predominant linear epitopes of Theiler's murine encephalomyelitis virus.Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease.Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating diseaseRelationship between host age and persistence of Theiler's virus in the central nervous system of mice.
P2860
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P2860
Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
description
1976 nî lūn-bûn
@nan
1976年の論文
@ja
1976年学术文章
@wuu
1976年学术文章
@zh-cn
1976年学术文章
@zh-hans
1976年学术文章
@zh-my
1976年学术文章
@zh-sg
1976年學術文章
@yue
1976年學術文章
@zh
1976年學術文章
@zh-hant
name
Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
@en
Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
@nl
type
label
Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
@en
Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
@nl
prefLabel
Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
@en
Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
@nl
P1476
Chronic neurologic disease in Theiler's virus infection of SJL/J mice.
@en
P2093
Dal Canto MC
P304
P356
10.1016/0022-510X(76)90267-7
P577
1976-11-01T00:00:00Z