Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
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Syntaxin 4 up-regulation increases efficiency of insulin release in pancreatic islets from humans with and without type 2 diabetes mellitusThe functional significance of synaptotagmin diversity in neuroendocrine secretionDoes disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes?Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cellsSynaptotagmin 11 interacts with components of the RNA-induced silencing complex RISC in clonal pancreatic β-cellsIncomplete Re-Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β-Cell Dedifferentiation.Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolismMicroRNA-7a regulates pancreatic β cell function.Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolismDownregulation of type II diabetes mellitus and maturity onset diabetes of young pathways in human pancreatic islets from hyperglycemic donors.Munc18c: a controversial regulator of peripheral insulin action.Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion.Calcium current inactivation rather than pool depletion explains reduced exocytotic rate with prolonged stimulation in insulin-secreting INS-1 832/13 cells.Doc2b serves as a scaffolding platform for concurrent binding of multiple Munc18 isoforms in pancreatic islet β-cellsEvidence of stress in β cells obtained with laser capture microdissection from pancreases of brain dead donors.Forkhead box O1 promotes INS‑1 cell apoptosis by reducing the expression of CD24.Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore ExpansionSingle-cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes.Commentary: ATP: The crucial component of secretory vesicles: Accelerated ATP/insulin exocytosis and prediabetes.Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.Type 2 diabetes mellitus in pediatrics: a new challenge.Role of non-coding RNAs in pancreatic beta-cell development and physiology.Functional implications of long non-coding RNAs in the pancreatic islets of Langerhans.Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell.Potential regulatory mechanisms of lncRNA in diabetes and its complications.Exocytosis proteins as novel targets for diabetes prevention and/or remediation?Identification of novel genes for glucose metabolism based upon expression pattern in human islets and effect on insulin secretion and glycemia.[Arfaptine-1 controls secretory granule biogenesis].MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles.Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men.Systems biology of the IMIDIA biobank from organ donors and pancreatectomised patients defines a novel transcriptomic signature of islets from individuals with type 2 diabetes.Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction.New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment.
P2860
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P2860
Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes.
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2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
@zh-hans
2012年学术文章
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name
Reduced insulin secretion corr ...... patients with type 2 diabetes.
@en
Reduced insulin secretion corr ...... patients with type 2 diabetes.
@nl
type
label
Reduced insulin secretion corr ...... patients with type 2 diabetes.
@en
Reduced insulin secretion corr ...... patients with type 2 diabetes.
@nl
prefLabel
Reduced insulin secretion corr ...... patients with type 2 diabetes.
@en
Reduced insulin secretion corr ...... patients with type 2 diabetes.
@nl
P2093
P50
P921
P1476
Reduced insulin secretion corr ...... patients with type 2 diabetes.
@en
P2093
Anders H Olsson
Anna Edlund
Claes Ladenvall
Emilia Heimann
Eva Degerman
Jonathan L S Esguerra
Sofia A Andersson
P356
10.1016/J.MCE.2012.08.009
P577
2012-08-23T00:00:00Z