about
Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neuronsCaspase-2 as a tumour suppressorStructure of the Drosophila Apoptosome at 6.9 Å ResolutionOld, new and emerging functions of caspases.Caspase-2-mediated cell death is required for deleting aneuploid cells.Putative functions of caspase-2.DRONC, an ecdysone-inducible Drosophila caspaseAn unexpected role for caspase-2 in neuroblastoma.Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient miceCaspase-2 deficiency promotes aberrant DNA-damage response and genetic instability.The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells.The role of cytochrome c in caspase activation in Drosophila melanogaster cells.Age-related proteostasis and metabolic alterations in Caspase-2-deficient miceA tumor suppressor function for caspase-2Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice.Caspase-2 protocols.Caspase-2 deficiency accelerates chemically induced liver cancer in mice.Caspase-2 protects against oxidative stress in vivo.ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity.Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY.Fat, sex and caspase-2.Genetic background and tumour susceptibility in mouse models.Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis.Analysing caspase activation and caspase activity in apoptotic cells.Caspase-2 is required for cell death induced by cytoskeletal disruption.A biochemical analysis of the activation of the Drosophila caspase DRONC.DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7.Characterization of the Drosophila caspase, DAMM.An essential role for the caspase dronc in developmentally programmed cell death in Drosophila.p53 accumulation following cytokinesis failure in the absence of caspase-2Insect CaspasesTumour necrosis factor alpha (TNF- ) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF- to activate nuclear factor B and reduced sphingosine kinase-1 activityA cytochrome c-free fly apoptosomeDifferential inhibitory effects of CrmA, P35, IAP and three mammalian IAP homologues on apoptosis in NIH3T3 cells following various death stimuliTranscriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signalingNew insights into apoptosome structure and function
P50
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P50
description
hulumtuese
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Loretta Dorstyn
@ast
Loretta Dorstyn
@en
Loretta Dorstyn
@es
Loretta Dorstyn
@nl
Loretta Dorstyn
@sl
type
label
Loretta Dorstyn
@ast
Loretta Dorstyn
@en
Loretta Dorstyn
@es
Loretta Dorstyn
@nl
Loretta Dorstyn
@sl
prefLabel
Loretta Dorstyn
@ast
Loretta Dorstyn
@en
Loretta Dorstyn
@es
Loretta Dorstyn
@nl
Loretta Dorstyn
@sl
P106
P21
P31
P496
0000-0001-9886-0989