The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.
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Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymesStructural Insight into the Tetramerization of an Iterative Ketoreductase SiaM through Aromatic Residues in the InterfacesSolution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthaseCrystal Structure of the Erythromycin Polyketide Synthase DehydrataseCrystal Structures of Dehydratase Domains from the Curacin Polyketide Biosynthetic PathwayStructural and Biochemical Analyses of Regio- and Stereospecificities Observed in a Type II Polyketide KetoreductaseThe Missing Linker: A Dimerization Motif Located within Polyketide Synthase ModulesStructural Studies of an A2-Type Modular Polyketide Synthase Ketoreductase Reveal Features Controlling α-Substituent StereochemistryStructural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-AlkeneDivergence of multimodular polyketide synthases revealed by a didomain structureThe Determinants of Activity and Specificity in Actinorhodin Type II Polyketide KetoreductaseStructural and functional studies of atrans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective α- and β-ketoreductionHeterologous expression and structural characterisation of a pyrazinone natural product assembly lineMycocerosic acid synthase exemplifies the architecture of reducing polyketide synthasesDomain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferaseArchitecture of the polyketide synthase module: surprises from electron cryo-microscopyKetoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitroBioinformatics Prediction of Polyketide Synthase Gene Clusters from Mycosphaerella fijiensisConformational flexibility of metazoan fatty acid synthase enables catalysisTrichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii BloomX-ray Scattering Studies of Protein Structural Dynamics.Solving the Puzzle of One-Carbon Loss in Ripostatin Biosynthesis.Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.Portability and Structure of the Four-Helix Bundle Docking Domains of trans-Acyltransferase Modular Polyketide Synthases.Structural enzymology of polyketide synthases.Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchangeSBSPKS: structure based sequence analysis of polyketide synthasesProgramming of erythromycin biosynthesis by a modular polyketide synthaseMechanism and stereospecificity of a fully saturating polyketide synthase module: nanchangmycin synthase module 2 and its dehydratase domain.Modeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study.Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthaseSources of diversity in bactobolin biosynthesis by Burkholderia thailandensis E264The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.Polyketide intermediate mimics as probes for revealing cryptic stereochemistry of ketoreductase domains.Structure-based dissociation of a type I polyketide synthase moduleThe type I fatty acid and polyketide synthases: a tale of two megasynthasesKetide Synthase (KS) Domain Prediction and Analysis of Iterative Type II PKS Gene in Marine Sponge-Associated Actinobacteria Producing Biosurfactants and Antimicrobial AgentsEpimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues.A ketoreductase domain in the PksJ protein of the bacillaene assembly line carries out both alpha- and beta-ketone reduction during chain growth.
P2860
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P2860
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
The structure of a ketoreducta ...... modular polyketide synthases.
@en
The structure of a ketoreducta ...... modular polyketide synthases.
@nl
type
label
The structure of a ketoreducta ...... modular polyketide synthases.
@en
The structure of a ketoreducta ...... modular polyketide synthases.
@nl
prefLabel
The structure of a ketoreducta ...... modular polyketide synthases.
@en
The structure of a ketoreducta ...... modular polyketide synthases.
@nl
P1433
P1476
The structure of a ketoreducta ...... modular polyketide synthases.
@en
P2093
Adrian T Keatinge-Clay
Robert M Stroud
P304
P356
10.1016/J.STR.2006.01.009
P577
2006-03-23T00:00:00Z