A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure.
about
Protein trafficking defects in inherited kidney diseasesIntegrity of Narrow Epithelial Tubes in the C. elegans Excretory System Requires a Transient Luminal MatrixCommon noncoding UMOD gene variants induce salt-sensitive hypertension and kidney damage by increasing uromodulin expressionIntegrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma.A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress.Renal localization and regulation by dietary phosphate of the MCT14 orphan transporterCommon variants in UMOD associate with urinary uromodulin levels: a meta-analysisStandardized, systemic phenotypic analysis of Umod(C93F) and Umod(A227T) mutant mice.Characterization of a recurrent in-frame UMOD indel mutation causing late-onset autosomal dominant end-stage renal failureHarvest and primary culture of the murine aldosterone-sensitive distal nephronUromodulin in kidney injury: an instigator, bystander, or protector?Mutant uromodulin expression leads to altered homeostasis of the endoplasmic reticulum and activates the unfolded protein response.Clinical, Genetic, and Urinary Factors Associated with Uromodulin ExcretionMup-knockout mice generated through CRISPR/Cas9-mediated deletion for use in urinary protein analysisUromodulin upregulates TRPV5 by impairing caveolin-mediated endocytosis.Plasma Uromodulin Correlates With Kidney Function and Identifies Early Stages in Chronic Kidney Disease Patients.Claudin-14 underlies Ca⁺⁺-sensing receptor-mediated Ca⁺⁺ metabolism via NFAT-microRNA-based mechanismsScraping fibrosis: UMODulating renal fibrosis.Uromodulin: from monogenic to multifactorial diseases.Renal allograft fibrosis: biology and therapeutic targets.Uromodulin: from physiology to rare and complex kidney disorders.From juvenile hyperuricaemia to dysfunctional uromodulin: an ongoing metamorphosis.Ways of calcium reabsorption in the kidney.The Uromodulin Gene Locus Shows Evidence of Pathogen Adaptation through Human Evolution.A novel homozygous UMOD mutation reveals gene dosage effects on uromodulin processing and urinary excretion.Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations.Renal phenotype in Bardet-Biedl syndrome: a combined defect of urinary concentration and dilution is associated with defective urinary AQP2 and UMOD excretion.Paradoxical response to furosemide in uromodulin-associated kidney disease.Determination of uromodulin in human urine: influence of storage and processing.Point mutation in D8C domain of Tamm-Horsfall protein/uromodulin in transgenic mice causes progressive renal damage and hyperuricemia.Elevated urinary CRELD2 is associated with endoplasmic reticulum stress-mediated kidney disease.Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis.Tamm-Horsfall Protein/Uromodulin Deficiency Elicits Tubular Compensatory Responses Leading to Hypertension and Hyperuricemia.Type of uromodulin mutation and allelic status influence onset and severity of uromodulin-associated kidney disease in mice.What can target kidney fibrosis?The importance of uromodulin as regulator of salt reabsorption along the thick ascending limbMechanism of Fibrosis in -Related Autosomal Dominant Tubulointerstitial Kidney Disease
P2860
Q27012909-2B4A5860-79FD-4D70-821C-FE260E1D184DQ27308141-38A8F2C6-26C2-4DA3-A14C-D96881400395Q30558974-CC37F930-5EB7-4BC0-8027-0950857A53CEQ33799049-CA9287B9-834D-4993-BEB7-EE20540A1773Q33830515-F6116474-62FF-4C2B-9B55-3C027993478EQ33852868-B70ED835-F1F8-45F6-8EA7-90EC823ECE96Q33974623-E8D1055C-4670-40B5-BED5-554C3EF14D08Q35036347-575920AA-659B-4223-964F-CBD750748A37Q35664578-7CC815F2-8D29-4D9F-8E3A-3B74FCB03708Q35671844-B77B45A4-BB41-4824-83DD-74E7DE48FD11Q35785284-E68DA615-519D-4C15-AD54-E5DD9A238080Q36355151-BC53ECE0-254B-4CA9-B66B-A2A5F40DF661Q36432914-DC07FA8C-A89F-4067-A035-7CF9929C4D0EQ36954821-393A075F-0D4C-47AF-BE43-756BD9F144DDQ36979830-432E154A-6FC3-43A2-861C-AA790585C7A3Q37207088-B974B6AC-3FF1-4D5F-B270-D79D8DC8AE5FQ37670320-1A716B64-51B3-4121-93EA-FB2429B79748Q37872592-57A899FF-C941-4578-8ACB-9D47ED6B9877Q38250313-0DF13162-A7D8-4F84-AE32-E949775B3C5AQ38359455-8E911BAC-A09F-48C4-AD2B-D63A09F7CF8DQ38638219-71FD0631-1FE0-4F5E-BBE6-749081F59DC2Q38731324-B9BAA71C-4DAC-44F4-8FB0-29B5660FE760Q38786641-36A18392-96D0-4765-BBEF-732A99F4483CQ39930066-C7AA7D72-3107-43E5-A30C-D9D1D0AF4D5FQ40176137-DCA0C924-CD98-467D-993E-882AA1CE467CQ41287767-AB857291-2739-40E9-9440-B193AE856884Q41630763-850FF029-A685-4D8F-84C8-01FC18099DDAQ41650636-70220CC8-C0F3-453E-BCA6-BA204D1636A0Q45985262-71D26A49-CD46-49E1-B9E0-51A481AB34FFQ46823378-EAEA1D94-4BBB-4A4C-BDF4-8F7F03F5837DQ47322029-44CD66A3-D47B-4065-BFE2-C47EAA3A2CB7Q47678474-26CF1A21-DD30-4F6A-B04F-DE31668DE34EQ47706305-ECA355A6-D7C8-42F3-BC96-6DFA6E867332Q50925005-3450C069-B82C-4AC5-89E4-C12941778327Q51066092-4E4F6942-E9A7-4E26-81A2-9313244477C6Q57716887-8635D3F6-D690-45AE-909F-6FDE6490C1FAQ58442482-BE5C7FA7-8E8E-48C8-99EB-D8FE2B5074DF
P2860
A transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh-hant
name
A transgenic mouse model for u ...... ting defect and renal failure.
@en
A transgenic mouse model for u ...... ting defect and renal failure.
@nl
type
label
A transgenic mouse model for u ...... ting defect and renal failure.
@en
A transgenic mouse model for u ...... ting defect and renal failure.
@nl
prefLabel
A transgenic mouse model for u ...... ting defect and renal failure.
@en
A transgenic mouse model for u ...... ting defect and renal failure.
@nl
P2093
P2860
P50
P356
P1476
A transgenic mouse model for u ...... ating defect and renal failure
@en
P2093
Alessandro Corbelli
Ilenia Bernascone
Maria Pia Rastaldi
Olivier Devuyst
Sylvie Janas
P2860
P304
P356
10.1093/HMG/DDQ205
P577
2010-05-14T00:00:00Z