An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis.
about
An expanded set of amino acid analogs for the ribosomal translation of unnatural peptidesBioorthogonal chemistry: fishing for selectivity in a sea of functionalityNicotine binding to brain receptors requires a strong cation-pi interactionProtein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structureStructural Consequences of β-Amino Acid Preorganization in a Self-Assembling α/β-Peptide: Fundamental Studies of Foldameric Helix BundlesFunctional probes of drug-receptor interactions implicated by structural studies: Cys-loop receptors provide a fertile testing groundIn vivo incorporation of non-canonical amino acids by using the chemical aminoacylation strategy: a broadly applicable mechanistic toolNicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH.Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics.Conserved thermodynamic contributions of backbone hydrogen bonds in a protein foldEvidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit.Site-specific incorporation of unnatural amino acids into proteins.Using thioamides to site-specifically interrogate the dynamics of hydrogen bond formation in β-sheet folding.Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.Binding interactions with the complementary subunit of nicotinic receptors.Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel.Multifrequency ESR study of spin-labeled molecules in inclusion compounds with cyclodextrins.Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis.Synthesis at the interface of chemistry and biology.An evaluation of peptide-bond isosteres.Ribosomal synthesis of backbone macrocyclic peptides.Toward quantification of protein backbone-backbone hydrogen bonding energies: An energetic analysis of an amide-to-ester mutation in an alpha-helix within a protein.Revisiting catalysis by chymotrypsin family serine proteases using peptide substrates and inhibitors with unnatural main chains.Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies.tRNA(2Gln) mutants that translate the CGA arginine codon as glutamine in Escherichia coli.Synthesis, folding, and structure of the beta-turn mimic modified B1 domain of streptococcal protein G.A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone estersn→π* interactions in poly(lactic acid) suggest a role in protein folding.Effects of hydrogen-bond deletion on peptide helices: structural characterization of depsipeptides containing lactic acid.A PEG-based oligomer as a backbone replacement for surface-exposed loops in a protein tertiary structure.Expected and unexpected results from combined beta-hairpin design elements.Ester vs. amide on folding: a case study with a 2-residue synthetic peptide.A molecular engineering toolbox for the structural biologist.Helices with additional H-bonds: crystallographic conformations of α,γ-hybrid peptides helices composed of β-hydroxy γ-amino acids (statines).Assessing the stability of alanine-based helices by conformer-selective IR spectroscopy.Probing backbone hydrogen bonding in PDZ/ligand interactions by protein amide-to-ester mutations.Design and Evaluation of Short Self-Assembling Depsipeptides as Bioactive and Biodegradable Hydrogels.
P2860
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P2860
An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
An experimental approach to ev ...... atural amino acid mutagenesis.
@en
An experimental approach to ev ...... atural amino acid mutagenesis.
@nl
type
label
An experimental approach to ev ...... atural amino acid mutagenesis.
@en
An experimental approach to ev ...... atural amino acid mutagenesis.
@nl
prefLabel
An experimental approach to ev ...... atural amino acid mutagenesis.
@en
An experimental approach to ev ...... atural amino acid mutagenesis.
@nl
P2093
P356
P1433
P1476
An experimental approach to ev ...... atural amino acid mutagenesis.
@en
P2093
P304
11314-11322
P356
10.1021/BI9707685
P407
P577
1997-09-01T00:00:00Z