Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.
about
The retinoblastoma protein binds to a family of E2F transcription factorsPurification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene productTwo distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigenRapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells.Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism.The retinoblastoma protein is phosphorylated on multiple sites by human cdc2Deficiency of coagulation factor XIII A subunit caused by the dinucleotide deletion at the 5' end of exon IIIOncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastomaANX7, a candidate tumor suppressor gene for prostate cancerDifferential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteinsMolecular pathology of prostate cancerAdvances in genetics: widening our understanding of prostate cancerStructural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigenStructure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7Tumor-suppressor genes: cardinal factors in inherited predisposition to human cancersAntisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis.Positive selection of candidate tumor-suppressor genes by subtractive hybridization.A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.Insights into cancer from transgenic mouse models.A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma.Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.Allelic loss of chromosomes 16q and 10q in human prostate cancer.Reversible tumorigenesis induced by deficiency of vasodilator-stimulated phosphoprotein.miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cellsIdentification and genetic analysis of cancer cells with PCR-activated cell sortingFunctional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression.Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor.Multiple members of the E2F transcription factor family are the products of oncogenesLoss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis.The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein.Oncogenes and tumor-suppressor genes.Inhibition of prostate cancer growth by vitamin D: Regulation of target gene expression.Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitorHyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities.Further characterization of retinoblastoma gene-mediated cell growth and tumor suppression in human cancer cellsDeletion of RB exons 24 and 25 causes low-penetrance retinoblastomaNuclear protein phosphorylation and growth control.Targeted tumor killing via an intracellular antibody against erbB-2.Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.
P2860
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P2860
Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh-hant
name
Suppression of tumorigenicity ...... y replacing a mutated RB gene.
@en
Suppression of tumorigenicity ...... y replacing a mutated RB gene.
@nl
type
label
Suppression of tumorigenicity ...... y replacing a mutated RB gene.
@en
Suppression of tumorigenicity ...... y replacing a mutated RB gene.
@nl
prefLabel
Suppression of tumorigenicity ...... y replacing a mutated RB gene.
@en
Suppression of tumorigenicity ...... y replacing a mutated RB gene.
@nl
P2093
P356
P1433
P1476
Suppression of tumorigenicity ...... y replacing a mutated RB gene.
@en
P2093
P304
P356
10.1126/SCIENCE.2300823
P407
P577
1990-02-01T00:00:00Z