Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice.
about
Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neuronsPharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.Tetrodotoxin (TTX) as a therapeutic agent for pain.Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma-1 receptor antagonist in three randomized phase I studies.Sigma-1 receptor and inflammatory pain.Sigma-1 receptors and animal studies centered on pain and analgesia.Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors.Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1).Mu opioids and their receptors: evolution of a concept.Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury.Fat location defines sensation.Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin.Genetic inactivation and pharmacological blockade of sigma-1 receptors prevent paclitaxel-induced sensory-nerve mitochondrial abnormalities and neuropathic pain in mice.Selective sigma-1 receptor antagonists for the treatment of pain.The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.Investigational sigma-1 receptor antagonists for the treatment of pain.Medicinal Chemistry of σ1 Receptor Ligands: Pharmacophore Models, Synthesis, Structure Affinity Relationships, and Pharmacological Applications.Opioid adjuvant strategy: improving opioid effectiveness.Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain.Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI.Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics.Sigma-1 receptor expression in the dorsal root ganglion: Reexamination using a highly specific antibody.Sigma1 Pharmacology in the Context of Cancer.The selective sigma-1 receptor antagonist E-52862 attenuates neuropathic pain of different aetiology in rats.Effects of Tetrodotoxin in Mouse Models of Visceral Pain.Inhibitory effects of sigma-2 receptor agonists on T lymphocyte activation.Thiazole-Based σ1 Receptor Ligands: Diversity by Late-Stage C-H Arylation of Thiazoles, Structure-Affinity and Selectivity Relationships, and Molecular Interactions.Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position.Novel Sigma-1 receptor antagonists: from opioids to small molecules: what is new?Structure-Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma.TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain.Fluorinated PET Tracers for Molecular Imaging of σ1 Receptors in the Central Nervous System.Sigma-1 Receptor and Neuronal Excitability.Comparison of in Silico, Electrochemical, in Vitro and in Vivo Metabolism of a Homologous Series of (Radio)fluorinated σ1 Receptor Ligands Designed for Positron Emission Tomography.Behavioural phenotyping of knockout mice for the sigma-1 (σ₁) chaperone protein revealed gender-related anxiety, depressive-like and memory alterations.Synthesis, σ receptor affinity, and pharmacological evaluation of 5-phenylsulfanyl- and 5-benzyl-substituted tetrahydro-2-benzazepines.Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice.Sigma-1 Receptor and Pain.The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation.Addressing the Issue of Tetrodotoxin Targeting
P2860
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P2860
Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: studies with selective sigma-1 ligands and sigma-1 knockout mice.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Sigma-1 receptors are essentia ...... nds and sigma-1 knockout mice.
@en
Sigma-1 receptors are essentia ...... nds and sigma-1 knockout mice.
@nl
type
label
Sigma-1 receptors are essentia ...... nds and sigma-1 knockout mice.
@en
Sigma-1 receptors are essentia ...... nds and sigma-1 knockout mice.
@nl
prefLabel
Sigma-1 receptors are essentia ...... nds and sigma-1 knockout mice.
@en
Sigma-1 receptors are essentia ...... nds and sigma-1 knockout mice.
@nl
P2093
P1433
P1476
Sigma-1 receptors are essentia ...... ands and sigma-1 knockout mice
@en
P2093
Cruz Miguel Cendán
Daniel Zamanillo
Enrique José Cobos
Esperanza Del Pozo
Francisco Rafael Nieto
Georgia Gris
José Manuel Baeyens
P304
P356
10.1016/J.PAIN.2009.03.011
P407
P577
2009-04-17T00:00:00Z