Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl species.
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Use of Carnosine for Oxidative Stress Reduction in Different Pathologies4-Hydroxy-nonenal-A Bioactive Lipid Peroxidation ProductCarnosinases, their substrates and diseasesDetoxification of aldehydes by histidine-containing dipeptides: from chemistry to clinical implicationsD-Carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation.A carnosine intervention study in overweight human volunteers: bioavailability and reactive carbonyl species sequestering effect.Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders.Protein modification by acrolein: relevance to pathological conditions and inhibition by aldehyde sequestering agents.Carnosine derivatives: new multifunctional drug-like molecules.Transforming dietary peptides in promising lead compounds: the case of bioavailable carnosine analogs.Acrolein effects in pulmonary cells: relevance to chronic obstructive pulmonary disease.Computational approaches in the rational design of improved carbonyl quenchers: focus on histidine containing dipeptides.Protection from diabetes-induced atherosclerosis and renal disease by D-carnosine-octylester: effects of early vs late inhibition of advanced glycation end-products in Apoe-null mice.Intrinsic carnosine metabolism in the human kidney.Carnosine: can understanding its actions on energy metabolism and protein homeostasis inform its therapeutic potential?FL-926-16, a novel bioavailable carnosinase-resistant carnosine derivative, prevents onset and stops progression of diabetic nephropathy in db/db mice.Carnosine metabolism in diabetes is altered by reactive metabolites.Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift.Predicting the physicochemical profile of diastereoisomeric histidine-containing dipeptides by property space analysis.
P2860
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P2860
Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl species.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
@zh-hant
name
Design, synthesis, and evaluat ...... xic reactive carbonyl species.
@en
Design, synthesis, and evaluat ...... xic reactive carbonyl species.
@nl
type
label
Design, synthesis, and evaluat ...... xic reactive carbonyl species.
@en
Design, synthesis, and evaluat ...... xic reactive carbonyl species.
@nl
prefLabel
Design, synthesis, and evaluat ...... xic reactive carbonyl species.
@en
Design, synthesis, and evaluat ...... xic reactive carbonyl species.
@nl
P2093
P50
P356
P1433
P1476
Design, synthesis, and evaluat ...... xic reactive carbonyl species.
@en
P2093
Alessandro Pedretti
Gianpaolo Negrisoli
Renato Canevotti
P304
P356
10.1002/CMDC.200800433
P577
2009-06-01T00:00:00Z