Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice. - Wikidata - wikimedia - TriplyDB

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.

http://www.wikidata.org/entity/Q46150766

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Epigenome-modifying tools in asthma Glucocorticoid insensitivity as a future target of therapy for chronic obstructive pulmonary disease Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases Aminophylline restores glucocorticoid sensitivity in a guinea pig model of sudden sensorineural hearing loss induced by lipopolysaccharide.Icariin ameliorates cigarette smoke induced inflammatory responses via suppression of NF-κB and modulation of GR in vivo and in vitro Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease.Pharmacological characterisation of anti-inflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation.Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ Glucocorticosteroids: current and future directions.Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes.The glucocorticoid receptor: a revisited target for toxins Biochemical basis of asthma therapy.Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial.Pharmacological Inhibition of O-GlcNAcase Does Not Increase Sensitivity of Glucocorticoid Receptor-Mediated Transrepression.T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease Preventive effect of N-acetylcysteine in a mouse model of steroid resistant acute exacerbation of asthma.Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease Molecular and cellular mechanisms of pulmonary fibrosis.The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation.Phosphoinositide 3-kinase-δ regulates fungus-induced allergic lung inflammation through endoplasmic reticulum stress Restoration of Corticosteroid Sensitivity in Chronic Obstructive Pulmonary Disease by Inhibition of Mammalian Target of Rapamycin.Corticosteroid insensitivity is reversed by formoterol via phosphoinositide-3-kinase inhibition Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo.Local and systemic oxidative stress status in chronic obstructive pulmonary disease patients.A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke.Anti-inflammatory dosing of theophylline in the treatment of status asthmaticus in children.Recent advances in pre-clinical mouse models of COPD.The respiratory syncytial virus (RSV) nonstructural proteins mediate RSV suppression of glucocorticoid receptor transactivation.Passive smoking impairs histone deacetylase-2 in children with severe asthma.Therapeutic targets for new therapy for corticosteroid refractory asthma.Histone deacetylase-2 and airway disease.Phosphatidylinositol 3-kinase isoforms as targets in respiratory disease.Update in chronic obstructive pulmonary disease 2009.The importance of epigenetics in the development of chronic obstructive pulmonary disease.Corticosteroid resistance and novel anti-inflammatory therapies in chronic obstructive pulmonary disease: current evidence and future direction.Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases.

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Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.

http://www.wikidata.org/entity/Q46150766

description

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name

Inhibition of PI3Kdelta restor ...... d airway inflammation in mice.

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Inhibition of PI3Kdelta restor ...... d airway inflammation in mice.

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type

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Inhibition of PI3Kdelta restor ...... d airway inflammation in mice.

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Inhibition of PI3Kdelta restor ...... d airway inflammation in mice.

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Inhibition of PI3Kdelta restor ...... d airway inflammation in mice.

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Inhibition of PI3Kdelta restor ...... d airway inflammation in mice.

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RCCM.200810-1570OC

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American Journal of Respiratory and Critical Care Medicine

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Inhibition of PI3Kdelta restor ...... d airway inflammation in mice.

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Alberto Papi

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Christopher S Stevenson

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Elen Jazrawi

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Gaetano Caramori

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John A Marwick

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Kazuhiro Ito

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Paolo Casolari

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Paul A Kirkham

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Peter J Barnes

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P2860

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression.

PI3K in lymphocyte development, differentiation and activation

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model

Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

DNA binding of the glucocorticoid receptor is not essential for survival.

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10.1164/RCCM.200810-1570OC

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19164702

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