about
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertensionStructural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targetingA conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signalingStructural basis for the activation of PPARgamma by oxidized fatty acidsStructural basis for the assembly of the SMRT/NCoR core transcriptional repression machineryThe ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domainThe oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformationThe crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elementsTowards an understanding of the structure and function of MTA1Solution structure of the DNA-binding domain of the oestrogen receptorInternational Union of Pharmacology. LXVI. Orphan nuclear receptorsSt John's wort, a herbal antidepressant, activates the steroid X receptor.Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cellsA novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemiaIdentification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans.Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation.STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cellsMechanism of corepressor binding and release from nuclear hormone receptors.Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance.Coexpression of nuclear receptor partners increases their solubility and biological activities.Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6)Mutations in TBL1X Are Associated With Central Hypothyroidism.Nuclear hormone receptor co-repressors: structure and function.An evolving understanding of nuclear receptor coregulator proteins.Transient expression in HEK 293 cells: an alternative to E. coli for the production of secreted and intracellular mammalian proteins.Histone deacetylase 3 indirectly modulates tubulin acetylationTargeting Class I Histone Deacetylases in a "Complex" Environment.Genetic disorders of nuclear receptors.Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell FateRecombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach.The structure of the core NuRD repression complex provides insights into its interaction with chromatin.Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.Insights into the activation mechanism of class I HDAC complexes by inositol phosphatesInsights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex.A specific mutation in TBL1XR1 causes Pierpont syndrome.Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins.NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis.
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
John Schwabe
@ast
John Schwabe
@en
John Schwabe
@es
John Schwabe
@nl
John Schwabe
@sl
type
label
John Schwabe
@ast
John Schwabe
@en
John Schwabe
@es
John Schwabe
@nl
John Schwabe
@sl
prefLabel
John Schwabe
@ast
John Schwabe
@en
John Schwabe
@es
John Schwabe
@nl
John Schwabe
@sl
P1053
A-9132-2008
P106
P21
P2798
P31
P3829
P496
0000-0003-2865-4383
P5463
Schwabe_John