An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.
about
Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivationMain roads to melanomaThe Wnt-dependent signaling pathways as target in oncology drug discoveryTargeting self-renewal pathways in cancer stem cells: clinical implications for cancer therapyTargeting the Wnt pathway in human cancers: therapeutic targeting with a focus on OMP-54F28The challenge of developmental therapeutics for adrenocortical carcinomaDickkopfs and Wnt/β-catenin signalling in liver cancerCanonical Wnt pathway inhibitor ICG-001 induces cytotoxicity of multiple myeloma cells in Wnt-independent mannerP120ctn overexpression enhances beta-catenin-E-cadherin binding and down regulates expression of survivin and cyclin D1 in BEL-7404 hepatoma cellsIdentification of genes regulated by Wnt/beta-catenin pathway and involved in apoptosis via microarray analysis.Caspase 2-mediated tumor suppression involves survivin gene silencing.Generation of a novel transgenic mouse model for bioluminescent monitoring of survivin gene activity in vivo at various pathophysiological processes: survivin expression overlaps with stem cell markersEll3 stimulates 5-FU resistance in a breast cancer cell line.Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy.SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signalingStriking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progressionExpression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer.Impaired Wnt signaling in embryonal rhabdomyosarcoma cells from p53/c-fos double mutant mice.A novel sLRP6E1E2 inhibits canonical Wnt signaling, epithelial-to-mesenchymal transition, and induces mitochondria-dependent apoptosis in lung cancer.WNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/β-catenin pathway.WNT2 regulates DNA synthesis in mouse granulosa cells through beta-cateninThe adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosisWNTS and WNT receptors as therapeutic tools and targets in human disease processes.Targeting breast cancer-initiating/stem cells with melanoma differentiation-associated gene-7/interleukin-24.Prognostic parameters for the primary care of melanoma patients: what is really risky in melanoma?Pathway profiling and rational trial design for studies in advanced stage cervical carcinoma: a review and a perspective.Induction of cancer cell death by isoflavone: the role of multiple signaling pathways.Polyphyllin I induces cell cycle arrest and apoptosis in human myeloma cells via modulating β-catenin signaling pathway.Role of survivin and its splice variants in tumorigenesisDiverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and PrognosisSurvivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AMLsiRNA-mediated beta-catenin knockdown in human hepatoma cells results in decreased growth and survivalInhibition of GSK-3beta as a target for cardioprotection: the importance of timing, location, duration and degree of inhibition.Wnt3a mitigates acute lung injury by reducing P2X7 receptor-mediated alveolar epithelial type I cell death.Identification of thiostrepton as a novel therapeutic agent that targets human colon cancer stem cells.The role of Wnt signaling in cancer and stem cells.Targeting Wnt pathways in disease.Emerging drugs for hepatocellular carcinoma.Targeting the Wnt signaling pathway to treat Barrett's esophagus.Small-molecule modulators of Hh and Wnt signaling pathways.
P2860
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P2860
An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
An anti-Wnt-2 monoclonal antib ...... lls and inhibits tumor growth.
@en
An anti-Wnt-2 monoclonal antib ...... lls and inhibits tumor growth.
@nl
type
label
An anti-Wnt-2 monoclonal antib ...... lls and inhibits tumor growth.
@en
An anti-Wnt-2 monoclonal antib ...... lls and inhibits tumor growth.
@nl
prefLabel
An anti-Wnt-2 monoclonal antib ...... lls and inhibits tumor growth.
@en
An anti-Wnt-2 monoclonal antib ...... lls and inhibits tumor growth.
@nl
P2093
P1433
P1476
An anti-Wnt-2 monoclonal antib ...... ells and inhibits tumor growth
@en
P2093
David M Jablons
Frank McCormick
Iwao Mikami
Joe K McIntosh
Kazutsugu Uematsu
Mohammed Kashani-Sabet
Naoaki Fujii
Noemi Reguart
P304
P356
10.1158/0008-5472.CAN-04-1227
P407
P577
2004-08-01T00:00:00Z