Specific interdomain synergy in the UapA transporter determines its unique specificity for uric acid among NAT carriers.
about
Transporter oligomerization: form and functionA diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients.Modelling and mutational analysis of Aspergillus nidulans UreA, a member of the subfamily of urea/H⁺ transporters in fungi and plantsPurine substrate recognition by the nucleobase-ascorbate transporter signature motif in the YgfO xanthine permease: ASN-325 binds and ALA-323 senses substrateCysteine-scanning analysis of helices TM8, TM9a, and TM9b and intervening loops in the YgfO xanthine permease: a carboxyl group is essential at ASP-276.Insights to the evolution of Nucleobase-Ascorbate Transporters (NAT/NCS2 family) from the Cys-scanning analysis of xanthine permease XanQIdentification of the substrate recognition and transport pathway in a eukaryotic member of the nucleobase-ascorbate transporter (NAT) familyOrigin, diversification and substrate specificity in the family of NCS1/FUR transporters.Structure-function relationship of a plant NCS1 member--homology modeling and mutagenesis identified residues critical for substrate specificity of PLUTO, a nucleobase transporter from Arabidopsis.The Aspergillus nidulans proline permease as a model for understanding the factors determining substrate binding and specificity of fungal amino acid transporters.The role of transmembrane segment TM3 in the xanthine permease XanQ of Escherichia coli.Substrate selectivity of YgfU, a uric acid transporter from Escherichia coli.Understanding transporter specificity and the discrete appearance of channel-like gating domains in transporters.Function and Regulation of Fungal Amino Acid Transporters: Insights from Predicted Structure.Assessing cancer cell migration and metastatic growth in vivo in the chick embryo using fluorescence intravital imaging.Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ.Role of intramembrane polar residues in the YgfO xanthine permease: HIS-31 and ASN-93 are crucial for affinity and specificity, and ASP-304 and GLU-272 are irreplaceable.Modeling, substrate docking, and mutational analysis identify residues essential for the function and specificity of a eukaryotic purine-cytosine NCS1 transporter.The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals.Substrate Specificity of the FurE Transporter Is Determined by Cytoplasmic Terminal Domain Interactions.Modelling and mutational evidence identify the substrate binding site and functional elements in APC amino acid transporters.Evolution of substrate specificity in the Nucleobase-Ascorbate Transporter (NAT) protein family.
P2860
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P2860
Specific interdomain synergy in the UapA transporter determines its unique specificity for uric acid among NAT carriers.
description
2008 nî lūn-bûn
@nan
2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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2008年學術文章
@zh-hant
name
Specific interdomain synergy i ...... uric acid among NAT carriers.
@en
Specific interdomain synergy i ...... uric acid among NAT carriers.
@nl
type
label
Specific interdomain synergy i ...... uric acid among NAT carriers.
@en
Specific interdomain synergy i ...... uric acid among NAT carriers.
@nl
prefLabel
Specific interdomain synergy i ...... uric acid among NAT carriers.
@en
Specific interdomain synergy i ...... uric acid among NAT carriers.
@nl
P2093
P921
P1476
Specific interdomain synergy i ...... uric acid among NAT carriers.
@en
P2093
Anna Vlanti
Areti Pantazopoulou
Christos Gournas
George Diallinas
Ioannis Papageorgiou
Sotiris Amillis
P304
P356
10.1016/J.JMB.2008.08.005
P407
P577
2008-08-07T00:00:00Z