Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses.
about
Discovery of Novel Irreversible Inhibitors of Interleukin (IL)-2-inducible Tyrosine Kinase (Itk) by Targeting Cysteine 442 in the ATP PocketThree mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors.Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses.Itk: the rheostat of the T cell response.Signal transduction and chemotaxis in mast cellsAssociation of mast cells with lung function in chronic obstructive pulmonary disease.The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses.The tyrosine kinase network regulating mast cell activation.TEC and MAPK Kinase Signalling Pathways in T helper (TH) cell Development, TH2 Differentiation and Allergic Asthma.ITK inhibitors in inflammation and immune-mediated disorders.Itk inhibitors: a patent review.Tec family kinases: regulation of FcεRI-mediated mast-cell activation.Acupoint Activation: Response in Microcirculation and the Role of Mast Cells.Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage.Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
P2860
Q27679513-574AF847-A8B0-48BA-8CE9-796239176712Q33266495-961B5543-5AC5-4076-A46E-8F0A8C2AA01BQ34241095-727224A3-6047-4B4C-9432-AF5F3DC9CFEDQ34685218-4F0C0598-1071-47BA-86E2-88DEABB8D18CQ35049534-85DD0AA9-BB6A-48DB-8F78-073A52AF0AF9Q36240848-E7A57D4A-70C1-4255-B89A-7860FBF81B29Q36889723-7944882E-CE12-437E-9FD8-72A7D810B9B1Q36974135-7147C1D9-1F09-46FA-8D23-C9BAE451D28DQ37158872-F989058C-FADC-47FB-A7CA-0B5125F4AD68Q37219806-F299347D-42F4-45D2-9909-BC1BD59CB872Q37581866-35940A45-B0B5-499C-8C47-CFDF4D127631Q37706622-AD192558-B3D4-4108-8324-3D8377894374Q37848482-0781362D-C570-4129-85A3-B529ACBF2A9DQ41165730-278743AD-EEAF-4E5E-B82C-FDD443078FB3Q49789558-D6C54CD2-7A95-4703-9DDD-DEC027980875Q53806651-66CD296D-F01A-4B29-8D27-7E6F708B7304
P2860
Interleukin-2-inducible T cell kinase regulates mast cell degranulation and acute allergic responses.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Interleukin-2-inducible T cell ...... and acute allergic responses.
@en
Interleukin-2-inducible T cell ...... and acute allergic responses.
@nl
type
label
Interleukin-2-inducible T cell ...... and acute allergic responses.
@en
Interleukin-2-inducible T cell ...... and acute allergic responses.
@nl
prefLabel
Interleukin-2-inducible T cell ...... and acute allergic responses.
@en
Interleukin-2-inducible T cell ...... and acute allergic responses.
@nl
P2093
P2860
P356
P1476
Interleukin-2-inducible T cell ...... and acute allergic responses.
@en
P2093
Christina Eriksson
Johan Forssell
Kristina Rydell-Törmänen
Monika Malm-Erjefält
Pascalis Sideras
Per-Olof Ericsson
P2860
P304
P356
10.1165/RCMB.2004-0348OC
P577
2005-03-18T00:00:00Z