Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
about
Plant sterols cause macrothrombocytopenia in a mouse model of sitosterolemia.The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia.Opposing Gatekeepers of Apical Sterol Transport: Niemann-Pick C1-Like 1 (NPC1L1) and ATP-Binding Cassette Transporters G5 and G8 (ABCG5/ABCG8)Xenobiotic, bile acid, and cholesterol transporters: function and regulation.Acceleration of biliary cholesterol secretion restores glycemic control and alleviates hypertriglyceridemia in obese db/db mice.NPC1L1 and cholesterol transportCholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice.Relative roles of ABCG5/ABCG8 in liver and intestine.The combination of ezetimibe and ursodiol promotes fecal sterol excretion and reveals a G5G8-independent pathway for cholesterol elimination.Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice.The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice.Protein mediators of sterol transport across intestinal brush border membrane.Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine.The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulationCholesterol absorption inhibitors as a therapeutic option for hypercholesterolaemia.Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport.The ABCG family of membrane-associated transporters: you don't have to be big to be mightyIntestinal and hepatic niemann-pick c1-like 1.NPC1L1 (Niemann-Pick C1-like 1) mediates sterol-specific unidirectional transport of non-esterified cholesterol in McArdle-RH7777 hepatoma cells.Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice.Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8.ABCG5 and ABCG8: more than a defense against xenosterolsSelective Compensatory Induction of Hepatic HMG-CoA Reductase in Response to Inhibition of Cholesterol Absorption
P2860
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P2860
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
description
2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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name
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
@en
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
@nl
type
label
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
@en
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
@nl
prefLabel
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
@en
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
@nl
P2093
P2860
P1476
Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8.
@en
P2093
Dieter Lütjohann
Helen H Hobbs
Jonathan C Cohen
Klaus von Bergmann
P2860
P304
P356
10.1194/JLR.M500124-JLR200
P577
2005-06-01T00:00:00Z