Response to: 'Denosumab, cortical bone and bone erosion in rheumatoid arthritis' by Rossini et al.

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Denosumab: targeting the RANKL pathway to treat rheumatoid arthritis.

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Response to: 'Denosumab, cortical bone and bone erosion in rheumatoid arthritis' by Rossini et al.

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2016 nî lūn-bûn

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Response to: 'Denosumab, corti ...... d arthritis' by Rossini et al.

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Response to: 'Denosumab, corti ...... d arthritis' by Rossini et al.

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Response to: 'Denosumab, corti ...... d arthritis' by Rossini et al.

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Harry K Genant

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Hisashi Yamanaka

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Naoki Ishiguro

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Naoki Okubo

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Takeshi Ohira

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Toshiyuki Yoneda

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Yoshiya Tanaka

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P2860

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose-response study of AMG 162 (Denosumab) in patients with RheumatoId arthritis on methotrexate

Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density.

Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention

Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength.

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts.

Denosumab, cortical bone and bone erosions in rheumatoid arthritis.

Denosumab rapidly increases cortical bone in key locations of the femur: a 3D bone mapping study in women with osteoporosis.

Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: A twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial

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10.1136/ANNRHEUMDIS-2016-210027

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Tsutomu Takeuchi

Désirée van der Heijde

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2016-08-23T00:00:00Z

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Response to: 'Denosumab, cortical bone and bone erosion in rheumatoid arthritis' by Rossini et al.

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Response to: 'Denosumab, cortical bone and bone erosion in rheumatoid arthritis' by Rossini et al.

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