Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
about
Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp studyNew magnetic resonance techniques for evaluating cerebrovascular disease.Magnetic resonance imaging of acute stroke.In vivo magnetic resonance methods in pharmaceutical research: current status and perspectives.Hypoxic and ischemic hypoxia exacerbate brain injury associated with metabolic encephalopathy in laboratory animals.Neuroprotective profile of lifarizine (RS-87476) in rat cerebrocortical neurones in culture.Drugs acting on calcium channels: potential treatment for ischaemic stroke.Neurocytotoxicity: pharmacological implications.Spreading waves of decreased diffusion coefficient after cortical stimulation in the rat brain.Contrast-enhanced perfusion-sensitive MR imaging in the diagnosis of cerebrovascular disorders.Diffusion-weighted NMR imaging: application to experimental focal cerebral ischemia.Clinical outcome in ischemic stroke predicted by early diffusion-weighted and perfusion magnetic resonance imaging: a preliminary analysis.[3H]-lifarizine, a high affinity probe for inactivated sodium channels.Actions of the novel neuroprotective agent, lifarizine (RS-87476), on voltage-dependent sodium currents in the neuroblastoma cell line, N1E-115.Block of human voltage-sensitive Na+ currents in differentiated SH-SY5Y cells by lifarizine.Neuroprotective efficacy of lifarizine (RS-87476) in a simplified rat survival model of 2 vessel occlusion.Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neuronesReduction by lifarizine of the neuronal damage induced by cerebral ischaemia in rodents.Neuroprotective properties of lifarizine compared with those of other agents in a mouse model of focal cerebral ischaemia.The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil.Navigated diffusion imaging of normal and ischemic human brain.Improved perfusion with rt-PA and hirulog in a rabbit model of embolic stroke.Neuroprotective effects of a novel broad-spectrum cation channel blocker, LOE 908 MS, on experimental focal ischemia: a multispectral study.Neuroanatomical distribution and binding properties of saxitoxin sites in the rat and turtle CNS.MR imaging of anisotropic and restricted diffusion by simultaneous use of spin and stimulated echoes.Diffusion-weighted interleaved echo-planar imaging with a pair of orthogonal navigator echoes.Apparent diffusion coefficient mapping of experimental focal cerebral ischemia using diffusion-weighted echo-planar imaging.
P2860
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P2860
Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年学术文章
@wuu
1991年学术文章
@zh
1991年学术文章
@zh-cn
1991年学术文章
@zh-hans
1991年学术文章
@zh-my
1991年学术文章
@zh-sg
1991年學術文章
@yue
1991年學術文章
@zh-hant
name
Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
@en
Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
@nl
type
label
Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
@en
Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
@nl
prefLabel
Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
@en
Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
@nl
P2093
P1433
P1476
Ischemic brain damage: reduction by sodium-calcium ion channel modulator RS-87476.
@en
P2093
Kucharczyk J
Mintorovitch J
Moseley ME
P304
P356
10.1148/RADIOLOGY.179.1.2006281
P407
P577
1991-04-01T00:00:00Z