Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells.
about
Inhibition of c-Abl kinase activity renders cancer cells highly sensitive to mitoxantroneHDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.A positive role for c-Abl in Atm and Atr activation in DNA damage response.Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutationsAnalyses of the combination of 6-MP and dasatinib in cell cultureRITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38.Imatinib sensitivity in BCR-ABL1-positive chronic myeloid leukemia cells is regulated by the remaining normal ABL1 allele.c-Abl downregulates the slow phase of double-strand break repair.Extensive analysis of the T315I substitution and detection of additional ABL mutations in progenitors and primitive stem cell compartment in a patient with tyrosine kinase inhibitor-resistant chronic myeloid leukemia.Clonal hematopoiesis in Philadelphia chromosome-negative bone marrow cells of chronic myeloid leukemia patients receiving dasatinib.
P2860
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P2860
Pharmacological inhibition of c-Abl compromises genetic stability and DNA repair in Bcr-Abl-negative cells.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
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2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
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2008年學術文章
@zh-hant
name
Pharmacological inhibition of ...... air in Bcr-Abl-negative cells.
@en
Pharmacological inhibition of ...... air in Bcr-Abl-negative cells.
@nl
type
label
Pharmacological inhibition of ...... air in Bcr-Abl-negative cells.
@en
Pharmacological inhibition of ...... air in Bcr-Abl-negative cells.
@nl
prefLabel
Pharmacological inhibition of ...... air in Bcr-Abl-negative cells.
@en
Pharmacological inhibition of ...... air in Bcr-Abl-negative cells.
@nl
P2093
P2860
P356
P1433
P1476
Pharmacological inhibition of ...... pair in Bcr-Abl-negative cells
@en
P2093
H van der Kuip
M Sonnenberg
W E Aulitzky
P2860
P2888
P304
P356
10.1038/ONC.2008.68
P407
P577
2008-03-24T00:00:00Z