Modeling disease in human ESCs using an efficient BAC-based homologous recombination system.
about
Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stabilityBacterial artificial chromosome mutagenesis using recombineeringHuman induced pluripotent stem cells for monogenic disease modelling and therapyThe genomic stability of induced pluripotent stem cellsHematopoietic stem cell engineering at a crossroadsEmerging Non-Canonical Functions and Regulation by p53: p53 and StemnessNon-integrative lentivirus drives high-frequency cre-mediated cassette exchange in human cellsRepair at single targeted DNA double-strand breaks in pluripotent and differentiated human cellsPuma is required for p53-induced depletion of adult stem cellsProgress and bottleneck in induced pluripotencyImmunogenicity of induced pluripotent stem cellsZFX controls the self-renewal of human embryonic stem cellsDynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instabilityFunctional analysis of the acetylation of human p53 in DNA damage responses.Targeted isolation of cloned genomic regions by recombineering for haplotype phasing and isogenic targeting.An effective approach to prevent immune rejection of human ESC-derived allografts.Phosphorylation stabilizes Nanog by promoting its interaction with Pin1Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells.Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation.Context-dependent enhancement of induced pluripotent stem cell reprogramming by silencing Puma.Targeting of the human coagulation factor IX gene at rDNA locus of human embryonic stem cells.Safety paradigm: genetic evaluation of therapeutic grade human embryonic stem cellsInvestigating human disease using stem cell models.Genomic editing tools to model human diseases with isogenic pluripotent stem cells.Global identification of target recognition and cleavage by the Microprocessor in human ES cellsPresent state and future perspectives of using pluripotent stem cells in toxicology researchDistinct allelic patterns of nanog expression impart embryonic stem cell population heterogeneity.A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells.Precise BAC targeting of genetically polymorphic mouse ES cellsSite-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease.Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors.In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases.Genetic correction of β-thalassemia patient-specific iPS cells and its use in improving hemoglobin production in irradiated SCID mice.Engineering Human Stem Cell Lines with Inducible Gene Knockout using CRISPR/Cas9Global identification of transcriptional regulators of pluripotency and differentiation in embryonic stem cells.A scalable approach to prevent teratoma formation of human embryonic stem cellsTargeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCsAssessing the risks of genotoxicity in the therapeutic development of induced pluripotent stem cells
P2860
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P2860
Modeling disease in human ESCs using an efficient BAC-based homologous recombination system.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Modeling disease in human ESCs ...... mologous recombination system.
@en
Modeling disease in human ESCs ...... mologous recombination system.
@nl
type
label
Modeling disease in human ESCs ...... mologous recombination system.
@en
Modeling disease in human ESCs ...... mologous recombination system.
@nl
prefLabel
Modeling disease in human ESCs ...... mologous recombination system.
@en
Modeling disease in human ESCs ...... mologous recombination system.
@nl
P2093
P1433
P1476
Modeling disease in human ESCs ...... mologous recombination system.
@en
P2093
Hoseok Song
Sun-Ku Chung
P356
10.1016/J.STEM.2009.11.016
P407
P577
2010-01-01T00:00:00Z