Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas.
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The interaction of angiocidin with tissue transglutaminaseTransglutaminase is a tumor cell and cancer stem cell survival factorNovel chemo-sensitizing agent, ERW1227B, impairs cellular motility and enhances cell death in glioblastomasExtracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury.Transglutaminase 2 expression is increased as a function of malignancy grade and negatively regulates cell growth in meningioma.Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic interventionTwo isoforms of tissue transglutaminase mediate opposing cellular fates.Calcium blockers decrease the bortezomib resistance in mantle cell lymphoma via manipulation of tissue transglutaminase activitiesTransglutaminase 2 inhibitors and their therapeutic role in disease states.Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells.Tissue transglutaminase: a new target to reverse cancer drug resistanceTransglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis.Tissue transglutaminase protects epithelial ovarian cancer cells from cisplatin-induced apoptosis by promoting cell survival signaling.TGM2 inhibition attenuates ID1 expression in CD44-high glioma-initiating cellsTissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity.Transglutaminase activation in neurodegenerative diseases.Pharmacotherapy for adults with tumors of the central nervous system.Doxorubicin induces the persistent activation of intracellular transglutaminase 2 that protects from cell deathMethylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1.Potential of transglutaminase 2 as a therapeutic target.TG2, a novel extracellular protein with multiple functions.Tissue transglutaminase, inflammation, and cancer: how intimate is the relationship?Transglutaminase 2 and NF-κB: an odd couple that shapes breast cancer phenotype.Tissue Transglutaminase (TG2)-Induced Inflammation in Initiation, Progression, and Pathogenesis of Pancreatic Cancer.Transglutaminase inhibitors: a patent review.TG2 and NF-κB Signaling Coordinates the Survival of Mantle Cell Lymphoma Cells via IL6-Mediated AutophagyTissue transglutaminase (TG2) is involved in the resistance of cancer cells to the histone deacetylase (HDAC) inhibitor vorinostat.Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5.GTP-binding-defective forms of tissue transglutaminase trigger cell death.Importance of Ca(2+)-dependent transamidation activity in the protection afforded by tissue transglutaminase against doxorubicin-induced apoptosis.Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of β-catenin and FOXO-1Tissue transgluaminase 2 expression in meningiomas.The transglutaminase 2 gene is aberrantly hypermethylated in gliomaDiscovery of potent and specific dihydroisoxazole inhibitors of human transglutaminase 2.A small molecule regulator of tissue transglutaminase conformation inhibits the malignant phenotype of cancer cellsPharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation
P2860
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P2860
Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Tissue transglutaminase 2 inhi ...... osensitivity in glioblastomas.
@en
Tissue transglutaminase 2 inhi ...... osensitivity in glioblastomas.
@nl
type
label
Tissue transglutaminase 2 inhi ...... osensitivity in glioblastomas.
@en
Tissue transglutaminase 2 inhi ...... osensitivity in glioblastomas.
@nl
prefLabel
Tissue transglutaminase 2 inhi ...... osensitivity in glioblastomas.
@en
Tissue transglutaminase 2 inhi ...... osensitivity in glioblastomas.
@nl
P2093
P1476
Tissue transglutaminase 2 inhi ...... osensitivity in glioblastomas.
@en
P2093
Chaitan Khosla
Keith M Rich
Michael R Chicoine
Ryuji Higashikubo
Xiao Zheng
P304
P356
10.1158/1535-7163.MCT-04-0328
P50
P577
2005-09-01T00:00:00Z