The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats.
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Future pharmacological treatments for substance use disordersDopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeysLack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in ratsN-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonistsMultiple ADH genes modulate risk for drug dependence in both African- and European-AmericansRole of cues and contexts on drug-seeking behaviourRecent methods for measuring dopamine D3 receptor occupancy in vivo: importance for drug developmentDifferential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeysStructure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective AntagonistMaking Sense of: Sensitization in SchizophreniaPharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addictionThe selective dopamine D3 receptor antagonists SB-277011A and NGB 2904 and the putative partial D3 receptor agonist BP-897 attenuate methamphetamine-enhanced brain stimulation reward in ratsCharacterization of the transport, metabolism, and pharmacokinetics of the dopamine D3 receptor-selective fluorenyl- and 2-pyridylphenyl amides developed for treatment of psychostimulant abuseEvidence for the role of dopamine D3 receptors in oral operant alcohol self-administration and reinstatement of alcohol-seeking behavior in miceThe neuropharmacology of relapse to food seeking: methodology, main findings, and comparison with relapse to drug seeking.Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in ratsDynamic neural responses to cue-reactivity paradigms in heroin-dependent users: an fMRI studyInhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanismOral administration of the NAALADase inhibitor GPI-5693 attenuates cocaine-induced reinstatement of drug-seeking behavior in rats.Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development.Anti-relapse medications: preclinical models for drug addiction treatment.Multisite, randomized, double-blind, placebo-controlled pilot clinical trial to evaluate the efficacy of buspirone as a relapse-prevention treatment for cocaine dependenceIs slow-onset long-acting monoamine transport blockade to cocaine as methadone is to heroin? Implication for anti-addiction medications.Levo-tetrahydropalmatine attenuates cocaine self-administration under a progressive-ratio schedule and cocaine discrimination in ratsDopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administrationIncreased vulnerability to cocaine in mice lacking dopamine D3 receptorsFenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans.Targeting the dopamine D3 receptor: an overview of drug design strategies.Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine.Influence of cocaine history on the behavioral effects of Dopamine D(3) receptor-selective compounds in monkeys.Medication of l-tetrahydropalmatine significantly ameliorates opiate craving and increases the abstinence rate in heroin users: a pilot studyMetabotropic glutamate receptor 7 modulates the rewarding effects of cocaine in rats: involvement of a ventral pallidal GABAergic mechanism.Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors.Sign-tracking predicts increased choice of cocaine over food in ratsCurrent perspectives on selective dopamine D(3) receptor antagonists as pharmacotherapeutics for addictions and related disorders.Nucleus accumbens dopamine/glutamate interaction switches modes to generate desire versus dread: D(1) alone for appetitive eating but D(1) and D(2) together for fearCocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic administration of GYKI 52466: a non-competitive AMPA receptor antagonist.Identifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.Evaluation of buspirone for relapse-prevention in adults with cocaine dependence: an efficacy trial conducted in the real world.The selective dopamine D3 receptor antagonist, SR 21502, reduces cue-induced reinstatement of heroin seeking and heroin conditioned place preference in rats.
P2860
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P2860
The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The novel dopamine D3 receptor ...... drug-seeking behavior in rats.
@en
The novel dopamine D3 receptor ...... drug-seeking behavior in rats.
@nl
type
label
The novel dopamine D3 receptor ...... drug-seeking behavior in rats.
@en
The novel dopamine D3 receptor ...... drug-seeking behavior in rats.
@nl
prefLabel
The novel dopamine D3 receptor ...... drug-seeking behavior in rats.
@en
The novel dopamine D3 receptor ...... drug-seeking behavior in rats.
@nl
P2093
P2860
P356
P1476
The novel dopamine D3 receptor ...... drug-seeking behavior in rats.
@en
P2093
Arlene C Pak
Charles R Ashby
Eliot L Gardner
Jeremy G Gilbert
Leah Gitajn
Zheng-Xiong Xi
P2860
P2888
P304
P356
10.1038/SJ.NPP.1300912
P407
P577
2005-10-05T00:00:00Z
P5875
P6179
1040085437