Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling.
about
Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectorsA novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi.Systematic analysis of insertions and deletions specific to nematode proteins and their proposed functional and evolutionary relevance.A homogeneous and nonisotopic assay for phosphatidylinositol 4-kinases.A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell typesIntracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂.Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposisCoxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication.Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctionsSHIP prevents lipopolysaccharide from triggering an antiviral response in miceA novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ.Crucial role of phosphatidylinositol 4-kinase IIIalpha in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling.Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.Foot-and-mouth disease virus replicates independently of phosphatidylinositol 4-phosphate and type III phosphatidylinositol 4-kinases.Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha.Enterovirus 3A facilitates viral replication by promoting PI4KB-ACBD3 interaction.Eat in or take away? How phosphatidylinositol 4-kinases feed the phospholipase C pathway with substrate.Architecture of the human PI4KIIIα lipid kinase complex.
P2860
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P2860
Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Design of drug-resistant allel ...... enesis and molecular modeling.
@en
Design of drug-resistant allel ...... enesis and molecular modeling.
@nl
type
label
Design of drug-resistant allel ...... enesis and molecular modeling.
@en
Design of drug-resistant allel ...... enesis and molecular modeling.
@nl
prefLabel
Design of drug-resistant allel ...... enesis and molecular modeling.
@en
Design of drug-resistant allel ...... enesis and molecular modeling.
@nl
P2093
P50
P356
P1433
P1476
Design of drug-resistant allel ...... enesis and molecular modeling.
@en
P2093
Balazs Toth
Galina Tuymetova
Kevan Shokat
Peter J Steinbach
Xiaohang Zhao
Zsofia Szentpetery
P304
P356
10.1021/BI7017927
P407
P577
2008-01-19T00:00:00Z