Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.
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Crystal structures of penicillin-binding protein 2 from penicillin-susceptible and -resistant strains of Neisseria gonorrhoeae reveal an unexpectedly subtle mechanism for antibiotic resistanceCrystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysisResistance to antibiotics targeted to the bacterial cell wallCrystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesisCrystal Structure of Cefditoren Complexed with Streptococcus pneumoniae Penicillin-Binding Protein 2X: Structural Basis for Its High Antimicrobial ActivityCommon alterations in PBP1a from resistant Streptococcus pneumoniae decrease its reactivity toward beta-lactams: structural insightsCrystal Structures of Biapenem and Tebipenem Complexed with Penicillin-Binding Proteins 2X and 1A from Streptococcus pneumoniaeUnusual Conformation of the SxN Motif in the Crystal Structure of Penicillin-Binding Protein A from Mycobacterium tuberculosisStructural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of CeftobiproleCrystal Structures of Bifunctional Penicillin-Binding Protein 4 from Listeria monocytogenesStructural and mechanistic studies of the orf12 gene product from the clavulanic acid biosynthesis pathwayCrystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistanceBiological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective.The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins.The requirement for pneumococcal MreC and MreD is relieved by inactivation of the gene encoding PBP1a.Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA.A highly conserved interaction involving the middle residue of the SXN active-site motif is crucial for function of class B penicillin-binding proteins: mutational and computational analysis of PBP 2 from N. gonorrhoeaeHighly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20.Point mutation in the group B streptococcal pbp2x gene conferring decreased susceptibility to beta-lactam antibiotics.Penicillin-Binding Protein Transpeptidase Signatures for Tracking and Predicting β-Lactam Resistance Levels in Streptococcus pneumoniae.Peptidoglycan biosynthesis machinery: a rich source of drug targets.Molecular mechanisms of β-lactam resistance in Streptococcus pneumoniae.Crystallization and preliminary crystallographic analysis of the transpeptidase domain of penicillin-binding protein 2B from Streptococcus pneumoniae.β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wallContribution of specific amino acid changes in penicillin binding protein 1 to amoxicillin resistance in clinical Helicobacter pylori isolates.Structural analysis of an "open" form of PBP1B from Streptococcus pneumoniae.Computational studies on the resistance of penicillin-binding protein 2B (PBP2B) of wild-type and mutant strains of Streptococcus pneumoniae against β-lactam antibiotics.Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness.Substitutions in PBP2b from β-Lactam-resistant Streptococcus pneumoniae Have Different Effects on Enzymatic Activity and Drug Reactivity.Attenuation of penicillin resistance in a peptidoglycan O-acetyl transferase mutant of Streptococcus pneumoniaeMechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies
P2860
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P2860
Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Crystal structure of penicilli ...... e in Streptococcus pneumoniae.
@en
Crystal structure of penicillin-binding protein 1a
@nl
type
label
Crystal structure of penicilli ...... e in Streptococcus pneumoniae.
@en
Crystal structure of penicillin-binding protein 1a
@nl
prefLabel
Crystal structure of penicilli ...... e in Streptococcus pneumoniae.
@en
Crystal structure of penicillin-binding protein 1a
@nl
P2093
P50
P1476
Crystal structure of penicilli ...... e in Streptococcus pneumoniae.
@en
P2093
Anne Marie Di Guilmi
Carlos Contreras-Martel
Thierry Vernet
Viviana Job
P304
P356
10.1016/J.JMB.2005.10.030
P407
P577
2005-11-09T00:00:00Z