Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas.
about
Respiratory complex I is essential to induce a Warburg profile in mitochondria-defective tumor cells.Heterogeneous genetic background of the association of pheochromocytoma/paraganglioma and pituitary adenoma: results from a large patient cohort.The "fast" and the "slow" modes of mitochondrial DNA degradation.A mutation screening of oncogenes, tumor suppressor gene TP53 and nuclear encoded mitochondrial complex I genes in oncocytic thyroid tumors.Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastomaHigh-resolution genomic profiling of thyroid lesions uncovers preferential copy number gains affecting mitochondrial biogenesis loci in the oncocytic variants.Mitochondrial DNA mutations distinguish bilateral multifocal renal oncocytomas from familial Birt-Hogg-Dubé tumorsA multi-parametric workflow for the prioritization of mitochondrial DNA variants of clinical interestPersistent damage induces mitochondrial DNA degradation.Platinum-induced mitochondrial DNA mutations confer lower sensitivity to paclitaxel by impairing tubulin cytoskeletal organization.Different mtDNA mutations modify tumor progression in dependence of the degree of respiratory complex I impairment.The Mitochondrial Complex(I)ty of Cancer.Mitochondrial dysfunction and potential anticancer therapy.Where Birt-Hogg-Dubé meets Cowden syndrome: mirrored genetic defects in two cases of syndromic oncocytic tumours.The Landscape of mtDNA Modifications in Cancer: A Tale of Two Cities.Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer.Mitochondrial DNA genotyping efficiently reveals clonality of synchronous endometrial and ovarian cancers.Unravelling the Effects of the Mutation m.3571insC/MT-ND1 on Respiratory Complexes Structural Organization.Mitochondrial genome instability in colorectal adenoma and adenocarcinoma.
P2860
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P2860
Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Somatic complex I disruptive m ...... ability in pituitary adenomas.
@en
Somatic complex I disruptive m ...... ability in pituitary adenomas.
@nl
type
label
Somatic complex I disruptive m ...... ability in pituitary adenomas.
@en
Somatic complex I disruptive m ...... ability in pituitary adenomas.
@nl
prefLabel
Somatic complex I disruptive m ...... ability in pituitary adenomas.
@en
Somatic complex I disruptive m ...... ability in pituitary adenomas.
@nl
P2093
P2860
P50
P356
P1476
Somatic complex I disruptive m ...... ability in pituitary adenomas.
@en
P2093
Alan MacKay
Antonio Melcarne
Erica Di Cesare
Francesco Maria Calabrese
Giovanna Cenacchi
Giuseppe Gasparre
Isabella Morra
Marcella Attimonelli
Maryou B K Lambros
P2860
P304
P356
10.1093/HMG/DDS422
P577
2012-10-09T00:00:00Z